Frequencies of Bcl6 Mutation in Lymphoma and Normal B Cells
| . | Mutated Cases/Clones (%) . | Mutation Frequency* . | |
|---|---|---|---|
| Whole Region (1.3 kb) . | Hot-Spot Region (603 bp) . | ||
| Lymphoma | |||
| MCL | 1/21 (4.8) | 0.37 × 10−4/bp | 0 × 10−4/bp |
| FL | 25/59 (42) | 6.0 × 10−4/bp | 9.28 × 10−4/bp |
| MALT | 19/45 (42) | 6.0 × 10−4/bp | 11.4 × 10−4/bp |
| Normal | |||
| MC | 1/24 (4) | 0.32 × 10−4/bp | 0.69 × 10−4/bp |
| FC | 13/24 (54) | 7.1 × 10−4/bp | 13.1 × 10−4/bp |
| . | Mutated Cases/Clones (%) . | Mutation Frequency* . | |
|---|---|---|---|
| Whole Region (1.3 kb) . | Hot-Spot Region (603 bp) . | ||
| Lymphoma | |||
| MCL | 1/21 (4.8) | 0.37 × 10−4/bp | 0 × 10−4/bp |
| FL | 25/59 (42) | 6.0 × 10−4/bp | 9.28 × 10−4/bp |
| MALT | 19/45 (42) | 6.0 × 10−4/bp | 11.4 × 10−4/bp |
| Normal | |||
| MC | 1/24 (4) | 0.32 × 10−4/bp | 0.69 × 10−4/bp |
| FC | 13/24 (54) | 7.1 × 10−4/bp | 13.1 × 10−4/bp |
Abbreviations: MCL, mantle cell lymphoma; FL, follicular lymphoma; MALT, MALT lymphoma; MC, mantle cell; FC, follicle center cell.
The mutation frequencies were calculated according to the formula: No. of Mutations/No. of Cases (clones) × Sequence Length Tested.