Table 1.

Sequence Similarities Among the unc-18 Proteins

Protein (GenBank No.)unc-18* (S66716) Munc-18-1 (L26087) Munc 18b (U19520) Munc-18c1-153 (U19521)
PSP  45% 52%  47%  92%  
unc-18   59%  54%  45% 
Munc-18-1    63%  53%  
Munc 18b    47% 
Protein (GenBank No.)unc-18* (S66716) Munc-18-1 (L26087) Munc 18b (U19520) Munc-18c1-153 (U19521)
PSP  45% 52%  47%  92%  
unc-18   59%  54%  45% 
Munc-18-1    63%  53%  
Munc 18b    47% 

Protein sequence identities were calculated with the Bestfit program.60 For a comparison of Sec1 genes, see Pevsner21 and Halachmi and Lev.62 

*

unc-18 was described in C elegans.51 55 

Munc-18-1 (or Munc 18a)47 has greater than 96% identity with mSec1,61 nSec1,52 and rbSec1.53 

Munc-18b46 is identical to muSec157 and 98% identical to Munc18-2.54 

F1-153

Tellam et al.46