Table 4.

Serum Anti–-ID IgG Titer Detected by ELISA in Serum Samples From MPS I Dogs Postinfusion

Dogs Time Postinfusion (mo)
04-1501 2 3 4-6 7-9 10-12
M2  0 2004-151 3,2004-151 3,2004-151,‡ 1,600 800-1,600  800  
M3  0  100  100  100 100  100  100  
M4  0  1004-151 100  100 200  100  100  
M5  0  100  400  ND 100  100  ND  
M6  0  <100  <100 <100  <100  <100  <100 
Dogs Time Postinfusion (mo)
04-1501 2 3 4-6 7-9 10-12
M2  0 2004-151 3,2004-151 3,2004-151,‡ 1,600 800-1,600  800  
M3  0  100  100  100 100  100  100  
M4  0  1004-151 100  100 200  100  100  
M5  0  100  400  ND 100  100  ND  
M6  0  <100  <100 <100  <100  <100  <100 

The titer is recorded as the dilution of serum giving a corrected OD reading of greater than two times each dog’s pretreatment serum OD.

Abbreviation: ND, sample not done.

F4-150

Preinfusion serum was taken from each dog directly before the first infusion and used an individual background OD for each dog.

F4-151

Marks the timing of later infusions where dogs received more than 1.

‡

Cyclosporine A treatment was initiated.

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