Phenotypic Profile of DCs From MM Patients Versus Normal Donors
| Cell-Surface Antigen . | Normal Donor DC (% of Ag expression) . | MMDC (% of Ag expression) . | P Value . |
|---|---|---|---|
| BM | |||
| HLA-DR | 88.6 ± 5.1 | 87.4 ± 5.4 | .67 |
| CD40 | 64 ± 19.8 | 79.9 ± 11.8 | .44 |
| CD54 | 77.5 ± 12.2 | 72.7 ± 10.5 | .59 |
| CD80 | 69.8 ± 10.8 | 75.0 ± 10.1 | .43 |
| CD86 | 54.8 ± 30.9 | 65.8 ± 16.3 | .48 |
| CD14 | 8.8 ± 11.5 | 8.3 ± 6.5 | .99 |
| CD38 | 3.3 ± 1.5 | 2.6 ± 0.9 | .46 |
| PB | |||
| HLA-DR | 94.7 ± 2.1 | 91.5 ± 5.1 | .24 |
| CD40 | 76.9 ± 26.4 | 80.7 ± 15.3 | .87 |
| CD54 | 84.9 ± 15.1 | 58.2 ± 26.0 | .14 |
| CD80 | 60.2 ± 32.1 | 47.3 ± 23.0 | .56 |
| CD86 | 91.9 ± 3.9 | 88.1 ± 7.4 | .41 |
| CD14 | 47.1 ± 13.7 | 35.3 ± 19.9 | .44 |
| CD38 | 3.5 ± 0.7 | 2.3 ± 0.6 | .18 |
| Cell-Surface Antigen . | Normal Donor DC (% of Ag expression) . | MMDC (% of Ag expression) . | P Value . |
|---|---|---|---|
| BM | |||
| HLA-DR | 88.6 ± 5.1 | 87.4 ± 5.4 | .67 |
| CD40 | 64 ± 19.8 | 79.9 ± 11.8 | .44 |
| CD54 | 77.5 ± 12.2 | 72.7 ± 10.5 | .59 |
| CD80 | 69.8 ± 10.8 | 75.0 ± 10.1 | .43 |
| CD86 | 54.8 ± 30.9 | 65.8 ± 16.3 | .48 |
| CD14 | 8.8 ± 11.5 | 8.3 ± 6.5 | .99 |
| CD38 | 3.3 ± 1.5 | 2.6 ± 0.9 | .46 |
| PB | |||
| HLA-DR | 94.7 ± 2.1 | 91.5 ± 5.1 | .24 |
| CD40 | 76.9 ± 26.4 | 80.7 ± 15.3 | .87 |
| CD54 | 84.9 ± 15.1 | 58.2 ± 26.0 | .14 |
| CD80 | 60.2 ± 32.1 | 47.3 ± 23.0 | .56 |
| CD86 | 91.9 ± 3.9 | 88.1 ± 7.4 | .41 |
| CD14 | 47.1 ± 13.7 | 35.3 ± 19.9 | .44 |
| CD38 | 3.5 ± 0.7 | 2.3 ± 0.6 | .18 |
DCs from MM patients and normal donors, from either BM or PB, were tested by immunofluorescence for cell-surface expression of HLA-DR, CD40, CD54, CD80, CD86, CD14, and CD38. Statistical differences were tested using the Student’s t-test.