Table 1. Increases of Plasma tHcy After... | American Society of Hematology

Table 1.

Increases of Plasma tHcy After an Oral Methionine Loading as a Function of MTHFR Genotypes

Study	PML tHcy Increase (μmol/L)
	MTHFR Genotype at nt 677
	No. of Subjects	C/C	C/T	T/T	P^*
Jacques et al, 1996⁶ ^†	365	17.9	18.5	18.2	NS
Cattaneo et al, 1997² ^†	231	14.4	14.8	18.6	.006
Legnani et al, 1997³ ^†	63	17.0	19.0	23.1	NS
Verhoef et al, 1997⁵ ^‡	318	23.6	26.4	27.7	<.05
Girelli et al, 1998¹ ^‡	415	23.6	23.6	25.5	NS

Study	PML tHcy Increase (μmol/L)
	MTHFR Genotype at nt 677
	No. of Subjects	C/C	C/T	T/T	P^*
Jacques et al, 1996⁶ ^†	365	17.9	18.5	18.2	NS
Cattaneo et al, 1997² ^†	231	14.4	14.8	18.6	.006
Legnani et al, 1997³ ^†	63	17.0	19.0	23.1	NS
Verhoef et al, 1997⁵ ^‡	318	23.6	26.4	27.7	<.05
Girelli et al, 1998¹ ^‡	415	23.6	23.6	25.5	NS

Values of PML tHcy increase are arithmetic means (

) or geometric means (

). The dose of oral methionine was 3.8 g/m² body surface area in the study by Cattaneo et al, and 100 mg/kg body weight in the other studies.

Abbreviation: NS, not significant.

Genotype T/T v genotype C/C.