Staging Classification of HD
| Stage I. | Involvement of a single lymph node region or lymphoid structure (spleen, thymus, Waldeyer’s ring), or involvement of a single extralymphatic site (IE). |
| Stage II. | Involvement of two or more lymph node regions on the same side of the diaphragm (II) which may be accompanied by localized contiguous involvement of an extralymphatic organ or site (IIE). The number of anatomic sites may be indicated by a numerical subscript. |
| Stage III. | Involvement of lymph node regions on both sides of the diaphragm (III) which may also be accompanied by involvement of the spleen (IIIS) or by localized contiguous involvement of an extralymphatic organ or site (IIIE). |
| Stage IV. | Diffuse or disseminated involvement of one or more extralymphatic organs or tissues, with or without associated lymph node involvement. |
| Stage I. | Involvement of a single lymph node region or lymphoid structure (spleen, thymus, Waldeyer’s ring), or involvement of a single extralymphatic site (IE). |
| Stage II. | Involvement of two or more lymph node regions on the same side of the diaphragm (II) which may be accompanied by localized contiguous involvement of an extralymphatic organ or site (IIE). The number of anatomic sites may be indicated by a numerical subscript. |
| Stage III. | Involvement of lymph node regions on both sides of the diaphragm (III) which may also be accompanied by involvement of the spleen (IIIS) or by localized contiguous involvement of an extralymphatic organ or site (IIIE). |
| Stage IV. | Diffuse or disseminated involvement of one or more extralymphatic organs or tissues, with or without associated lymph node involvement. |
Notes: (1) The absence or presence of fever (>38°C) and/or unexplained weight loss (>10% of body weight) in the preceding 6 months are denoted by the suffix letters A and B, respectively. (2) If staging laparotomy/splenectomy has been performed the designation is pathological stage (PS), if not clinical stage (CS). (3) Stage III may be subdivided into III1 to designate involvement of only the upper abdominal nodes and/or spleen, and III2 to designate involvement of the paraaortic and/or pelvic nodes. (4) A mediastinal mass >maximum chest diameter or a lymphoid mass >10 cm in diameter may be designated by the subscript “x.”
Data from Carbone et al,6 Lister et al,7 and Gobbi et al.8