Table 2. Comparison of the Inhibitory... | American Society of Hematology

Table 2.

Comparison of the Inhibitory Capacity (ID 50) of the Different IVIG Preparations on Complement Deposition in an In Vitro Assay

	IVIG Preparation
	IVIgM	Pentaglobin	IVIgG	IVIgA
NHS
C1q	0.80	1.70	25	—^*
C4	0.08	0.30	8	—
C3	0.08	0.40	11	—
NHS + C4-def. gp^†
C4	0.30	1.80	16	—
C1q-depleted NHS
C4	0.90	0.60	9	19
C3	0.40	0.60	7	16

	IVIG Preparation
	IVIgM	Pentaglobin	IVIgG	IVIgA
NHS
C1q	0.80	1.70	25	—^*
C4	0.08	0.30	8	—
C3	0.08	0.40	11	—
NHS + C4-def. gp^†
C4	0.30	1.80	16	—
C1q-depleted NHS
C4	0.90	0.60	9	19
C3	0.40	0.60	7	16

The amount of IVIG in mg/mL is given, which was necessary to obtain a 50% inhibition (ID 50) of the binding of the respective complement component to the coated aIgG.

No inhibition.

†

C4-deficient guinea pig serum.

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