Table 1. Summary of DFO- and... | American Society of Hematology

Table 1.

Summary of DFO- and HBED-Induced Iron Excretion inCebus apella Monkeys

Drug	Dosage (μmol/kg [mg/kg])	Route	Vehicle	Induced Iron (μg/kg)	Efficiency (%)	Iron Balance (μg/kg)
DFO	300 [200]	PO	dH₂O	21 ± 65	0.1 ± 0.4	NS
HBED	324 [149.3]	PO	Buffer	57 ± 46	0.3 ± 0.3	NS
DFO^*	150 [100]	sc	dH₂O	435 ± 115	5.1 ± 1.3	−278 ± 185
HBED	150 [64.9]	sc	Saline	1,139 ± 383	13.6 ± 4.5	−899 ± 365
DFO	300 [200]	sc	dH₂O	716 ± 244	4.2 ± 1.4	−711 ± 230
HBED	324 [149.3]	sc	Buffer	2,400 ± 808	13.3 ± 4.5	−2,346 ± 830
HBED	81 [37.3]	sc	Buffer	608 ± 175	13.0 ± 4.6	−259 ± 209
HBED	225 [97.2] (75 μmol/kg × three doses)	sc	Saline	1,837 ± 301	14.6 ± 2.4	−1,578 ± 345
HBED	324 [149.3] (162 μmol/kg × two doses)	sc	Buffer	1,798 ± 210	9.9 ± 2.1	−1,607 ± 372

Drug	Dosage (μmol/kg [mg/kg])	Route	Vehicle	Induced Iron (μg/kg)	Efficiency (%)	Iron Balance (μg/kg)
DFO	300 [200]	PO	dH₂O	21 ± 65	0.1 ± 0.4	NS
HBED	324 [149.3]	PO	Buffer	57 ± 46	0.3 ± 0.3	NS
DFO^*	150 [100]	sc	dH₂O	435 ± 115	5.1 ± 1.3	−278 ± 185
HBED	150 [64.9]	sc	Saline	1,139 ± 383	13.6 ± 4.5	−899 ± 365
DFO	300 [200]	sc	dH₂O	716 ± 244	4.2 ± 1.4	−711 ± 230
HBED	324 [149.3]	sc	Buffer	2,400 ± 808	13.3 ± 4.5	−2,346 ± 830
HBED	81 [37.3]	sc	Buffer	608 ± 175	13.0 ± 4.6	−259 ± 209
HBED	225 [97.2] (75 μmol/kg × three doses)	sc	Saline	1,837 ± 301	14.6 ± 2.4	−1,578 ± 345
HBED	324 [149.3] (162 μmol/kg × two doses)	sc	Buffer	1,798 ± 210	9.9 ± 2.1	−1,607 ± 372

Net iron balance = dietary iron intake − (urinary iron + fecal iron). Animals in a negative iron balance are excreting more iron than they are absorbing.

Abbreviation: NS, not significant.

Previously published.26

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