Table 5. Comparison of the Beneficial... | American Society of Hematology

Table 5.

Comparison of the Beneficial and Harmful Effects of G-CSF on Infectious Lung Injury in Patients

Effect of G-CSF on Infectious Lung Injury	Effect of G-CSF on Clinical Parameters	Model	Reference
↑	+	One neutropenic, immunosuppressed patient with adult respiratory distress syndrome	157
↑	−	3/9 patients with drug-induced agranulocytosis with pre-existing life-threatening infection	158
↓	+	One patient with adult respiratory distress syndrome during chemotherapy	163
↓	+	One patient with alcoholism, leukopenia, and pneumococcal sepsis	91
∅︀	+	20 postoperative/posttraumatic patients at risk of or with sepsis	165
∅︀	∅︀	44 patients with acute traumatic brain injury or cerebral hemorrhage	114
↓	+	756 hospitalized patients with community-acquired pneumonia	164

Effect of G-CSF on Infectious Lung Injury	Effect of G-CSF on Clinical Parameters	Model	Reference
↑	+	One neutropenic, immunosuppressed patient with adult respiratory distress syndrome	157
↑	−	3/9 patients with drug-induced agranulocytosis with pre-existing life-threatening infection	158
↓	+	One patient with adult respiratory distress syndrome during chemotherapy	163
↓	+	One patient with alcoholism, leukopenia, and pneumococcal sepsis	91
∅︀	+	20 postoperative/posttraumatic patients at risk of or with sepsis	165
∅︀	∅︀	44 patients with acute traumatic brain injury or cerebral hemorrhage	114
↓	+	756 hospitalized patients with community-acquired pneumonia	164

Abbreviations: ↑, harmful; ∅︀, no effect; ↓, beneficial; +, improved; −, worsened.