Table 2. Summary of Detected Band 3... | American Society of Hematology

Table 2.

Summary of Detected Band 3 Mutations

Blood Group	No. of Subjects	Codon	Triplet	Amino Acid	Band 3 Loop	Conserved	Restriction Site Abrogated	Restriction Site Created
ELO	2	432	CGG → TGG	Arg → Trp	1	4/5, 4/12	Msp I, Nci I	BstNI
Vg^a	2^*	555	TAC → CAC	Tyr → His	3	N/A, N/A^†		Dra III
BOW	2	561	CCC → TCC	Pro → Ser	3	3/5, 10/12	Ban I	BstEII
Wu	6	565	GGC → GCC	Gly → Ala	3	3/5, N/A^†	Apa I
Bp^a	2	569	AAC → AAA	Asn → Lys	3	5/5, 12/12	Tth 2^‡
Hg^a	4	656	CGT → TGT	Arg → Cys	4	1/5, 1/12		Cac8I
Mo^a	2	656	CGT → CAT	Arg → His	4	3/5, 3/12		Bsm I

Blood Group	No. of Subjects	Codon	Triplet	Amino Acid	Band 3 Loop	Conserved	Restriction Site Abrogated	Restriction Site Created
ELO	2	432	CGG → TGG	Arg → Trp	1	4/5, 4/12	Msp I, Nci I	BstNI
Vg^a	2^*	555	TAC → CAC	Tyr → His	3	N/A, N/A^†		Dra III
BOW	2	561	CCC → TCC	Pro → Ser	3	3/5, 10/12	Ban I	BstEII
Wu	6	565	GGC → GCC	Gly → Ala	3	3/5, N/A^†	Apa I
Bp^a	2	569	AAC → AAA	Asn → Lys	3	5/5, 12/12	Tth 2^‡
Hg^a	4	656	CGT → TGT	Arg → Cys	4	1/5, 1/12		Cac8I
Mo^a	2	656	CGT → CAT	Arg → His	4	3/5, 3/12		Bsm I

Both subjects from the same family.

†

Because of deletions and insertion in band 3 homologues from evolutionarily older species, the degree of conservation cannot be established in this region of putative third ectoplasmic loop.

‡

Restriction endonuclease Tth 2 is not commercially available.

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