IL-10 Enhances the Transformation of B Cells
| Experiment . | Cells/ Well . | Control . | IL-10 . | ||
|---|---|---|---|---|---|
| Incidence of Growth . | Mean cpm . | Incidence of Growth . | Mean cpm . | ||
| 1 | 1.5 × 104 | 1/4 | 606 | 4/4 | 11,737 |
| 2 | 1.5 × 104 | 1/4 | 597 | 4/4 | 8,116 |
| 3 | 2.5 × 104 | 0/4 | 147 | 4/4 | 22,200 |
| Experiment . | Cells/ Well . | Control . | IL-10 . | ||
|---|---|---|---|---|---|
| Incidence of Growth . | Mean cpm . | Incidence of Growth . | Mean cpm . | ||
| 1 | 1.5 × 104 | 1/4 | 606 | 4/4 | 11,737 |
| 2 | 1.5 × 104 | 1/4 | 597 | 4/4 | 8,116 |
| 3 | 2.5 × 104 | 0/4 | 147 | 4/4 | 22,200 |
PBL were infected with EBV and cultured with or without 100 U/mL of hIL-10 in flat-bottomed microtiter plates at the indicated cell concentration/well. Four to 5 weeks later the cultures were visually scored for incidence of transformation. Proliferation was evaluated by3H-TdR incorporation. The SD of the replicates was ≤12%.