Patient Data and Results of First Marrow Grafts
| Years of Transplant Group Denomination . | 1970-1976 Group 1 . | 1977-1981 Group 2 . | 1982-1996 Group 3 . |
|---|---|---|---|
| No. of patients studied | 81 | 104 | 148 |
| Median age in years (range) | 17.3 (1.9-60.3) | 19.7 (3.0-53.4) | 23.6 (1.8-59.0) |
| Median (range) months from diagnosis to transplant | 2.3 (0.8-108.3) | 1.3 (0.33-75) | 1.8 (0.5-228.3) |
| Preceding transfusions (%) | 74 (91) | 72 (69) | 116 (78) |
| Preparative regimen (no. of patients) | |||
| CY 200 mg/kg | 62 | 104 | 96 |
| CY 200 mg/kg + procarbazine + ATG 36 mg/kg | 19 | 0 | 0 |
| CY 200 mg/kg + ATG 90 mg/kg | 0 | 0 | 52 |
| GVHD prophylaxis | |||
| Methotrexate | 81 | 86 | 29 |
| Cyclosporine | 0 | 13 | 3 |
| Methotrexate + cyclosporine | 0 | 5 | 116 |
| Median marrow cell dose ×108/kg (range) | 3.5 (1.0-14.0) | 3.2 (1.2-15.5) | 2.9 (0.4-11.3) |
| Buffy coat infusion (no. of patients) | 6 | 72 | 47 |
| No. of patients (%) | |||
| Rejecting | 28 (35) | 12 (12) | 13 (9) |
| Surviving | 34 (42) | 64 (61) | 108 (74) |
| Median days from transplant to rejection (range) | 28 (14-984) | 47 (14-215) | 180 (22-583) |
| Years of Transplant Group Denomination . | 1970-1976 Group 1 . | 1977-1981 Group 2 . | 1982-1996 Group 3 . |
|---|---|---|---|
| No. of patients studied | 81 | 104 | 148 |
| Median age in years (range) | 17.3 (1.9-60.3) | 19.7 (3.0-53.4) | 23.6 (1.8-59.0) |
| Median (range) months from diagnosis to transplant | 2.3 (0.8-108.3) | 1.3 (0.33-75) | 1.8 (0.5-228.3) |
| Preceding transfusions (%) | 74 (91) | 72 (69) | 116 (78) |
| Preparative regimen (no. of patients) | |||
| CY 200 mg/kg | 62 | 104 | 96 |
| CY 200 mg/kg + procarbazine + ATG 36 mg/kg | 19 | 0 | 0 |
| CY 200 mg/kg + ATG 90 mg/kg | 0 | 0 | 52 |
| GVHD prophylaxis | |||
| Methotrexate | 81 | 86 | 29 |
| Cyclosporine | 0 | 13 | 3 |
| Methotrexate + cyclosporine | 0 | 5 | 116 |
| Median marrow cell dose ×108/kg (range) | 3.5 (1.0-14.0) | 3.2 (1.2-15.5) | 2.9 (0.4-11.3) |
| Buffy coat infusion (no. of patients) | 6 | 72 | 47 |
| No. of patients (%) | |||
| Rejecting | 28 (35) | 12 (12) | 13 (9) |
| Surviving | 34 (42) | 64 (61) | 108 (74) |
| Median days from transplant to rejection (range) | 28 (14-984) | 47 (14-215) | 180 (22-583) |