Fas Mutations in 16 Lymphomas
| No. . | Histology . | Nucleotide Change* . | Localization . | Codon . | Predicted Effect . |
|---|---|---|---|---|---|
| 193 | B-CLL | G240A | Exon 2 | Signal peptide | Ala → Thr |
| 49 | FCC + DLC-B (TRB) | 598 ins T | Exon 4 | 119 | Frameshift |
| 128 | DLC-B | C732T | Exon 6 | 164 | Leu → Phe |
| 72 | ALCL null | C742T | Exon 6 | 167 | Pro → Leu |
| 157 | DLC-B (TRB) | C787T | Exon 7 | 182 | Thr → Ile |
| 69 | DLC-B | T838A | Exon 7 | 199 | Leu → STOP |
| 225 | DLC-B | IVS7nt − 2a → g | Intron 7 | — | Splice defect |
| 146 | MALT | IVS8nt + 5g → a | Intron 8 | — | Splice defect |
| 67 | MALT | IVS8nt + 5g → c | Intron 8 | — | Splice defect |
| 92 | DLC-B | T865G | Exon 8 | 208 | Leu → STOP |
| 86 | DLC-B | A973T | Exon 9 | 244 | Asp → Val |
| 156 | DLC-B | T986A | Exon 9 | 248 | Asn → Lys |
| 145 | MALT | T986G | Exon 9 | 248 | Asn → Lys |
| 17 | FCC | G1008A | Exon 9 | 256 | Glu → Lys |
| 93 | DLC-B | C1026T | Exon 9 | 262 | Leu → Phe |
| 141 | DLC-B | A1091T | Exon 9 | 283 | Lys → Asn |
| No. . | Histology . | Nucleotide Change* . | Localization . | Codon . | Predicted Effect . |
|---|---|---|---|---|---|
| 193 | B-CLL | G240A | Exon 2 | Signal peptide | Ala → Thr |
| 49 | FCC + DLC-B (TRB) | 598 ins T | Exon 4 | 119 | Frameshift |
| 128 | DLC-B | C732T | Exon 6 | 164 | Leu → Phe |
| 72 | ALCL null | C742T | Exon 6 | 167 | Pro → Leu |
| 157 | DLC-B (TRB) | C787T | Exon 7 | 182 | Thr → Ile |
| 69 | DLC-B | T838A | Exon 7 | 199 | Leu → STOP |
| 225 | DLC-B | IVS7nt − 2a → g | Intron 7 | — | Splice defect |
| 146 | MALT | IVS8nt + 5g → a | Intron 8 | — | Splice defect |
| 67 | MALT | IVS8nt + 5g → c | Intron 8 | — | Splice defect |
| 92 | DLC-B | T865G | Exon 8 | 208 | Leu → STOP |
| 86 | DLC-B | A973T | Exon 9 | 244 | Asp → Val |
| 156 | DLC-B | T986A | Exon 9 | 248 | Asn → Lys |
| 145 | MALT | T986G | Exon 9 | 248 | Asn → Lys |
| 17 | FCC | G1008A | Exon 9 | 256 | Glu → Lys |
| 93 | DLC-B | C1026T | Exon 9 | 262 | Leu → Phe |
| 141 | DLC-B | A1091T | Exon 9 | 283 | Lys → Asn |
*Numbering according to GenBank accession no. M67454; ALCL, anaplastic large cell lymphoma; FCC, follicle center cell lymphoma.