Clinical Characteristics of CML Patients
| Sample . | Age . | Sex . | Phenotype . | Blast (%)-150 . | Karyotype-151 . |
|---|---|---|---|---|---|
| CML1 | 48 | M | Myeloid | 20 | 46,XY,t(9;22)(q34:q11) |
| CML2 | 69 | F | Myeloid | 85 | 46,XX,t(9;22)(q34:q11) |
| CML3 | 39 | F | Myeloid | 50 | NA |
| CML4 | 33 | M | Myeloid | 30 | 46,XY,t(9;22)(q34:q11) |
| CML5 | 45 | M | Myeloid | 10 | 46,XY,t(9;22)(q34:q11) |
| CML6 | 45 | M | Myeloid | 65 | 47,XY,t(9;22)(q34:q11),+der(22)t(9;22)(q34:q11) |
| CML7 | 19 | M | Myeloid | 30 | 47,XY,t(9;22)(q34:q11),+der(22)t(9;22)(q34:q11) |
| CML8 | 33 | F | Myeloid | 21 | NA |
| CML9 | 38 | M | Myeloid | NA | 46,XY,der(3)t(3;7)(p13;p13),der(7)t(3;7)(p23;p13),t(9;22)(q34:q11) |
| CML10 | 39 | F | Myeloid | 16 | 46,XX,del(2)(q?),t(9;22)(q34:q11),add(11)(q?),add(15)(q?) |
| CML11 | 60 | F | Myeloid | 90 | 46,XX,t(9;22)(q34:q11) |
| CML12 | 60 | M | Myeloid | 75 | 46,XY |
| CML13 | 52 | M | Myeloid | 70 | 45,X,−Y,t(9;22)(q34:q11) |
| CML14 | 50 | M | Myeloid | 60 | 46,XY |
| CML15 | 73 | M | Myeloid | 57 | 46,XY,t(9;22)(q34:q11) |
| CML16 | 52 | M | Myeloid | 66 | 48,XY,+8,t(9;22)(q34:q11),+der(22)t(9;22)(q34:q11) |
| CML17 | 52 | F | Myeloid | 58 | 46,XX,t(9;22)(q34:q11) |
| CML18 | 61 | F | Myeloid | 64 | 46,XX,t(9;22)(q34:q11) |
| CML19 | 57 | F | Myeloid | 72 | 46,XX,t(1;21)(q32;q21),t(9;22)(q34:q11) |
| CML20 | 50 | M | Myeloid | 70 | 46,XY,t(9;22)(q34:q11) |
| CML21 | 53 | F | Myeloid | 90 | 46,XX,t(9;22)(q34:q11) |
| CML22 | 62 | M | Lymphoid | 40 | NA |
| CML23 | 38 | M | Lymphoid | 82 | 47,XY,+?der(1)t(1;20)(q21;q11.2)del(1)(p11),−9,t(9;22)(q34:q11),+18, der(20)t(1;20)(q21;q11.2) |
| CML24 | 38 | F | Lymphoid | 60 | 47,XX,t(9;22)(q34:q11),+i(17)(q10) |
| CML25 | 31 | M | Lymphoid | 90 | 46,XY,t(9;22)(q34:q11) |
| CML26 | 34 | F | Lymphoid | 10 | 46,XX,t(9;22)(q34:q11) |
| CML27 | 48 | M | Lymphoid | 65 | 46,XY,t(9;22)(q34:q11) |
| CML28 | 60 | M | Lymphoid | 40 | 46,XY,t(9;22)(q34:q11) |
| CML29 | 38 | F | Lymphoid | 45 | 46,XX,t(9;22)(q34:q11) |
| CML30 | 52 | F | Lymphoid | 46 | 46,XX,t(9;22)(q34:q11) |
| Sample . | Age . | Sex . | Phenotype . | Blast (%)-150 . | Karyotype-151 . |
|---|---|---|---|---|---|
| CML1 | 48 | M | Myeloid | 20 | 46,XY,t(9;22)(q34:q11) |
| CML2 | 69 | F | Myeloid | 85 | 46,XX,t(9;22)(q34:q11) |
| CML3 | 39 | F | Myeloid | 50 | NA |
| CML4 | 33 | M | Myeloid | 30 | 46,XY,t(9;22)(q34:q11) |
| CML5 | 45 | M | Myeloid | 10 | 46,XY,t(9;22)(q34:q11) |
| CML6 | 45 | M | Myeloid | 65 | 47,XY,t(9;22)(q34:q11),+der(22)t(9;22)(q34:q11) |
| CML7 | 19 | M | Myeloid | 30 | 47,XY,t(9;22)(q34:q11),+der(22)t(9;22)(q34:q11) |
| CML8 | 33 | F | Myeloid | 21 | NA |
| CML9 | 38 | M | Myeloid | NA | 46,XY,der(3)t(3;7)(p13;p13),der(7)t(3;7)(p23;p13),t(9;22)(q34:q11) |
| CML10 | 39 | F | Myeloid | 16 | 46,XX,del(2)(q?),t(9;22)(q34:q11),add(11)(q?),add(15)(q?) |
| CML11 | 60 | F | Myeloid | 90 | 46,XX,t(9;22)(q34:q11) |
| CML12 | 60 | M | Myeloid | 75 | 46,XY |
| CML13 | 52 | M | Myeloid | 70 | 45,X,−Y,t(9;22)(q34:q11) |
| CML14 | 50 | M | Myeloid | 60 | 46,XY |
| CML15 | 73 | M | Myeloid | 57 | 46,XY,t(9;22)(q34:q11) |
| CML16 | 52 | M | Myeloid | 66 | 48,XY,+8,t(9;22)(q34:q11),+der(22)t(9;22)(q34:q11) |
| CML17 | 52 | F | Myeloid | 58 | 46,XX,t(9;22)(q34:q11) |
| CML18 | 61 | F | Myeloid | 64 | 46,XX,t(9;22)(q34:q11) |
| CML19 | 57 | F | Myeloid | 72 | 46,XX,t(1;21)(q32;q21),t(9;22)(q34:q11) |
| CML20 | 50 | M | Myeloid | 70 | 46,XY,t(9;22)(q34:q11) |
| CML21 | 53 | F | Myeloid | 90 | 46,XX,t(9;22)(q34:q11) |
| CML22 | 62 | M | Lymphoid | 40 | NA |
| CML23 | 38 | M | Lymphoid | 82 | 47,XY,+?der(1)t(1;20)(q21;q11.2)del(1)(p11),−9,t(9;22)(q34:q11),+18, der(20)t(1;20)(q21;q11.2) |
| CML24 | 38 | F | Lymphoid | 60 | 47,XX,t(9;22)(q34:q11),+i(17)(q10) |
| CML25 | 31 | M | Lymphoid | 90 | 46,XY,t(9;22)(q34:q11) |
| CML26 | 34 | F | Lymphoid | 10 | 46,XX,t(9;22)(q34:q11) |
| CML27 | 48 | M | Lymphoid | 65 | 46,XY,t(9;22)(q34:q11) |
| CML28 | 60 | M | Lymphoid | 40 | 46,XY,t(9;22)(q34:q11) |
| CML29 | 38 | F | Lymphoid | 45 | 46,XX,t(9;22)(q34:q11) |
| CML30 | 52 | F | Lymphoid | 46 | 46,XX,t(9;22)(q34:q11) |
Abbreviations: M, male; F, female; NA, not available.
Blast (%) at BC or AP.
Karyotype at BC or AP.
All but two individuals (CML nos. 12 and 14) had Ph chromosome at diagnosis. Rearrangement of the BCR gene was detected at diagnosis by Southern blot analysis for CML nos. 12 and 14. Four samples were from AP patients (CML nos. 1, 5, 10, and 26).