Table 1.

Number of CD34-Enriched Cells Infused, Hematopoietic Recovery, and Survival in Baboons Transplanted With Genetically Marked CD34+ Cells

Baboon No. No. of CD34Enriched Cells/kg ×106 Before Culture (% CD34+)Transduction Conditions for Indicated VectorNo. of CD34Enriched Cells Infused/kg ×106 (LNX/LN) (total) ANC-150 >500/μLSurvival in Months (cause of death)
LNX LN
T95096  4.8 (94%)  48-h cocultivation, IL-3, IL-6, SCF, PS 48-h CH-296, IL-3, IL-6, SCF  1.9/2.0 (3.9)  12  >13 
F94424  4.6 (97%)  48-h cocultivation, IL-3, IL-6, SCF, PS 48-h CH-296, IL-3, IL-6, SCF  0.45/1.8 (2.25)  11 1 (sepsis)  
T94397  5.7 (83%)  48-h cocultivation, IL-3, IL-6, SCF, PS  48-h CH-296, IL-3, IL-6, SCF, PS 0.7/1.3 (2.0)  20  >10  
J95009  7.5 (83%)  72-h cocultivation, IL-3, IL-6, SCF, PS  72-h CH-296, IL-6, SCF, FLT3L, MGDF, PS  3.7/4.4 (8.1)  14  >9  
T94433  8.4 (90%) 72-h cocultivation, IL-6, SCF, FLT3L, MGDF, PS  72-h CH-296, IL-6, SCF, FLT3L, MGDF, PS  4.5/5.5 (10)  13  >8  
M94123 7.0 (90%)  72-h BSA, IL-6, SCF, FLT3L, MGDF, PS  72-h CH-296, IL-6, SCF, FLT3L, MGDF, PS  5.3/4.7 (10)  11 >6 
Baboon No. No. of CD34Enriched Cells/kg ×106 Before Culture (% CD34+)Transduction Conditions for Indicated VectorNo. of CD34Enriched Cells Infused/kg ×106 (LNX/LN) (total) ANC-150 >500/μLSurvival in Months (cause of death)
LNX LN
T95096  4.8 (94%)  48-h cocultivation, IL-3, IL-6, SCF, PS 48-h CH-296, IL-3, IL-6, SCF  1.9/2.0 (3.9)  12  >13 
F94424  4.6 (97%)  48-h cocultivation, IL-3, IL-6, SCF, PS 48-h CH-296, IL-3, IL-6, SCF  0.45/1.8 (2.25)  11 1 (sepsis)  
T94397  5.7 (83%)  48-h cocultivation, IL-3, IL-6, SCF, PS  48-h CH-296, IL-3, IL-6, SCF, PS 0.7/1.3 (2.0)  20  >10  
J95009  7.5 (83%)  72-h cocultivation, IL-3, IL-6, SCF, PS  72-h CH-296, IL-6, SCF, FLT3L, MGDF, PS  3.7/4.4 (8.1)  14  >9  
T94433  8.4 (90%) 72-h cocultivation, IL-6, SCF, FLT3L, MGDF, PS  72-h CH-296, IL-6, SCF, FLT3L, MGDF, PS  4.5/5.5 (10)  13  >8  
M94123 7.0 (90%)  72-h BSA, IL-6, SCF, FLT3L, MGDF, PS  72-h CH-296, IL-6, SCF, FLT3L, MGDF, PS  5.3/4.7 (10)  11 >6 

Abbreviations: ANC, absolute neutrophil count; BSA, bovine serum albumin; PS, protamine sulfate.

F0-150

Day to reach a sustained neutrophil count greater than 500/μL.

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