Marrow Hematopoietic Progenitor Cell Levels After the Administration of BAH-1, TPO, Control MoAb, or TPO plus BAH-1 to Myelosuppressed Mice
| Treatment . | CFU-MK (×10−3) . | BFU-E (×10−3) Experiment 1 . | CFU-GM (×10−3) Experiment 1 . | ||
|---|---|---|---|---|---|
| Experiment 1 . | Experiment 2 . | Experiment 3 . | |||
| Control | 0 | 0 | 0 | 2.0 ± 1.0 | 9.0 ± 1.0 |
| TPO | 10.5 ± 0.5-150 | 3.0 ± 1.0-150 | 7.5 ± 1.0-150 | 7.0 ± 1.0-150 | 50.5 ± 9.5-150 |
| BAH-1 | 1.0 ± 0 | 2.0 ± 1.0 | 2.0 ± 1.0 | 2.5 ± 1.0 | 12.0 ± 1.0 |
| BAH-1 + TPO | 12.0 ± 1.0-150 | 4.5 ± 0.5-150 | 12.5 ± 1.0-150 | 7.5 ± 0.5-150 | ND |
| Treatment . | CFU-MK (×10−3) . | BFU-E (×10−3) Experiment 1 . | CFU-GM (×10−3) Experiment 1 . | ||
|---|---|---|---|---|---|
| Experiment 1 . | Experiment 2 . | Experiment 3 . | |||
| Control | 0 | 0 | 0 | 2.0 ± 1.0 | 9.0 ± 1.0 |
| TPO | 10.5 ± 0.5-150 | 3.0 ± 1.0-150 | 7.5 ± 1.0-150 | 7.0 ± 1.0-150 | 50.5 ± 9.5-150 |
| BAH-1 | 1.0 ± 0 | 2.0 ± 1.0 | 2.0 ± 1.0 | 2.5 ± 1.0 | 12.0 ± 1.0 |
| BAH-1 + TPO | 12.0 ± 1.0-150 | 4.5 ± 0.5-150 | 12.5 ± 1.0-150 | 7.5 ± 0.5-150 | ND |
The results for femoral progenitors in each experiment represent the mean ± SEM of three animals in Experiments 1 and 2, whereas Experiment 3 included five animals in each treatment group.
Abbreviation: ND, not determined.
P < .005 compared with control.