Hematopoietic Stem Cell Numbers at 20 Weeks After Completion of a Six-Cycle Administration of Cytotoxic Agents
| Treatment . | CAFC-28/HL (95% CI) . | P Value*,† . | CAFC-35/HL (95% CI) . | P Value*,† . | RU/HL . | PValue* . |
|---|---|---|---|---|---|---|
| Saline | 949 (732-1,229) | — | 674 (500-908) | — | 438 ± 90 (12) | — |
| VP-16 + cisplatinum | NA | NA | 426 ± 76 (6) | .84 | ||
| Cyclophosphamide | 2,805 (1,916-4,106) | <.05 | 362 (199-660) | NS | 610 ± 121 (14) | .43 |
| Carboplatinum | 487 (362-656) | <.05 | 290 (188-285) | <.05 | 244 ± 79 (10) | .12 |
| Chlorambucil | 1,631 (1,273-2,090) | <.05 | 371 (278-496) | <.05 | 135 ± 12 (6) | <.01 |
| BCNU | 1,470 (1,001-2,158) | NS | 222 (134-368) | <.01 | 122 ± 13 (19) | <.01 |
| TBI | 582 (450-753) | NS | 298 (173-512) | NS | 31 ± 8 (8) | <.01 |
| Treatment . | CAFC-28/HL (95% CI) . | P Value*,† . | CAFC-35/HL (95% CI) . | P Value*,† . | RU/HL . | PValue* . |
|---|---|---|---|---|---|---|
| Saline | 949 (732-1,229) | — | 674 (500-908) | — | 438 ± 90 (12) | — |
| VP-16 + cisplatinum | NA | NA | 426 ± 76 (6) | .84 | ||
| Cyclophosphamide | 2,805 (1,916-4,106) | <.05 | 362 (199-660) | NS | 610 ± 121 (14) | .43 |
| Carboplatinum | 487 (362-656) | <.05 | 290 (188-285) | <.05 | 244 ± 79 (10) | .12 |
| Chlorambucil | 1,631 (1,273-2,090) | <.05 | 371 (278-496) | <.05 | 135 ± 12 (6) | <.01 |
| BCNU | 1,470 (1,001-2,158) | NS | 222 (134-368) | <.01 | 122 ± 13 (19) | <.01 |
| TBI | 582 (450-753) | NS | 298 (173-512) | NS | 31 ± 8 (8) | <.01 |
CAFC frequencies were determined from pooled marrow from 3 to 5 mice per experiment, the average frequency was calculated from 1 to 3 experiments with 95% confidence intervals (CI) (given in parentheses). RU/HL was calculated from 6 to 19 recipients (n given in parentheses) that had received marrow pooled from 3 to 5 treated mice; 1 to 3 separate competitive repopulation assays were performed (see Materials and Methods for details).
Abbreviations: NA, not available; NS, not significant.
P values are for comparison with saline.
P values for CAFC-28/35 are shown as <.05 (.01 < P < .05), <.01 (.001 < P < .01) or as P < .001.