Table 1. Effect of BM-Cell Coating With... | American Society of Hematology

Table 1.

Effect of BM-Cell Coating With Anti-Adhesion Molecule MoAbs on Colony Growth In Vitro and In Vivo

BM-Cell Treatment^-150	CFU-GM		BFU-E		Day-12 CFU-S
Control Ig	120 ± 31^-151		9		31 ± 4
		(n = 4)^-152		(n = 2)		(n = 3)
Anti-CD44	111 ± 27		10		26 ± 5
Control Ig	126 ± 32		30 ± 20		31 ± 3
		(n = 4)		(n = 3)		(n = 4)
Anti–VLA-4	107 ± 27		28 ± 17		30 ± 7
Control Ig	126 ± 7		23 ± 14		27 ± 1
		(n = 3)		(n = 3)		(n = 3)
Anti-CD11a	90 ± 18		21 ± 10		21 ± 5

BM-Cell Treatment^-150	CFU-GM		BFU-E		Day-12 CFU-S
Control Ig	120 ± 31^-151		9		31 ± 4
		(n = 4)^-152		(n = 2)		(n = 3)
Anti-CD44	111 ± 27		10		26 ± 5
Control Ig	126 ± 32		30 ± 20		31 ± 3
		(n = 4)		(n = 3)		(n = 4)
Anti–VLA-4	107 ± 27		28 ± 17		30 ± 7
Control Ig	126 ± 7		23 ± 14		27 ± 1
		(n = 3)		(n = 3)		(n = 3)
Anti-CD11a	90 ± 18		21 ± 10		21 ± 5

Comparison of the number of colonies generated by BM cells coated with control rat Ig versus tested antibody was statistically nonsignificant in all cases.

F0-150

10⁷ cells were incubated with 20 μg antibody or rat Ig for 30 minutes on ice and washed.

F0-151

Mean ± SEM of the number of colonies/10⁵ BM cells.

F0-152

n = number of experiments.

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