Table 4. Serum Vitamin and Metabolite... | American Society of Hematology

Table 4.

Serum Vitamin and Metabolite Concentrations Before and After 4 Months of Therapy in Patients Randomized to Parenteral Cyanocobalamin

Patient No.	Therapy^*	Serum Cobalamin (pg/mL)^3-151		Serum Folate (ng/mL)^3-151		Serum Methylmalonic Acid (nmol/L)^3-151		Serum Total Homocysteine (μmol/L)^3-151
Patient No.	Therapy^*	Pre^3-152	4 mo^3-152	Pre	4 mo	Pre	4 mo	Pre	4 mo
19	IM	90	170	9.0	4.9	22,200	339	45.0	14.5
20	IM	35	190	14.4	13.8	19,600	852	100.8	8.5
21	IM	70	350	2.6	2.7	2,510	238	70.9	9.1
22	IM	75	635	10.0	5.7	1,760	289	55.2	12.9
23	IM	45	175	5.4	5.7	1,170	370	23.9	10.0
24	IM	80	200	4.7	6.7	1,280	170	55.2	9.3
25	IM	30	230	8.3	8.5	1,070	444	71.8	11.4
26	IM	95	380	4.1	6.1	1,010	219	38.3	12.1
27	IM	170	390	3.4	3.9	665	120	14.4	19.0
28	IM	160	365	2.5	2.5	659	166	21.6	18.1
29	IM	110	295	3.4	3.7	502	172	26.0	17.3
30	IM	50	175	4.0^3-153	13.7	421	177	21.3	8.4
31	IM	120	—^3-155	5.1	6.1	418	188	11.4	7.5
32	IM	155	690	25.6	50.2	396	136	10.4	7.5
33	IM	140	300	3.4	1.8	272	96	34.3	17.8
Mean ± SD	IM	95 ± 92	325 ± 165	7.1 ± 6.1	9.1 ± 11.9	3,630 ± 7,040	265 ± 190	40.0 ± 26.2	12.2 ± 4.1

Patient No.	Therapy^*	Serum Cobalamin (pg/mL)^3-151		Serum Folate (ng/mL)^3-151		Serum Methylmalonic Acid (nmol/L)^3-151		Serum Total Homocysteine (μmol/L)^3-151
Patient No.	Therapy^*	Pre^3-152	4 mo^3-152	Pre	4 mo	Pre	4 mo	Pre	4 mo
19	IM	90	170	9.0	4.9	22,200	339	45.0	14.5
20	IM	35	190	14.4	13.8	19,600	852	100.8	8.5
21	IM	70	350	2.6	2.7	2,510	238	70.9	9.1
22	IM	75	635	10.0	5.7	1,760	289	55.2	12.9
23	IM	45	175	5.4	5.7	1,170	370	23.9	10.0
24	IM	80	200	4.7	6.7	1,280	170	55.2	9.3
25	IM	30	230	8.3	8.5	1,070	444	71.8	11.4
26	IM	95	380	4.1	6.1	1,010	219	38.3	12.1
27	IM	170	390	3.4	3.9	665	120	14.4	19.0
28	IM	160	365	2.5	2.5	659	166	21.6	18.1
29	IM	110	295	3.4	3.7	502	172	26.0	17.3
30	IM	50	175	4.0^3-153	13.7	421	177	21.3	8.4
31	IM	120	—^3-155	5.1	6.1	418	188	11.4	7.5
32	IM	155	690	25.6	50.2	396	136	10.4	7.5
33	IM	140	300	3.4	1.8	272	96	34.3	17.8
Mean ± SD	IM	95 ± 92	325 ± 165	7.1 ± 6.1	9.1 ± 11.9	3,630 ± 7,040	265 ± 190	40.0 ± 26.2	12.2 ± 4.1

*IM indicates intramuscular therapy.

Normal ranges and conversion factors for serum vitamin concentrations as indicated in footnote to Table 2.

Pre and 4 mo as in footnote to Table 3.

After 1 week of oral folic acid at 1 mg/d; previous serum folate level was less than 1.0 ng/mL.

Value excluded from analysis due to error in sampling immediately after parenteral dose.