Candidate Genes Mapped to Regions of Amplification Identified by CGH
| Chromosomal Region . | Candidate Genes . | Normal Function . | Amplification in Tumorigenesis . |
|---|---|---|---|
| 1q21-23 | IL6R | Signal transduction (receptor)13 | |
| MCL1 | Apoptosis (BCL2 family member)14 | ||
| SKI | Transcription factor15 | ||
| 2p12-16 | REL | Transcription factor16 | DLBL6 |
| 8q24 | MYC | Transcription factor17 | Breast carcinoma,18 Ovarian carcinoma,19FCL20 |
| 9q34 | ABL | Signal transduction (kinase)21 | |
| TAN1 | Signal transduction (receptor)22 | ||
| 12q12-14 | CDK2 | Cell cycle kinase23 | Colorectal carcinoma24 |
| GLI | Transcription factor25 | Gliomas,26Sarcomas27 | |
| SAS | Transmembrane protein28 | Gliomas,29 Sarcomas28 | |
| CDK4 | Cell cycle kinase23 | Gliomas,29 Sarcomas30 | |
| MDM2 | p53 inactivation31 | Gliomas,29Sarcomas30 | |
| 13q32 | — | — | — |
| 16p12 | IL4R | Signal transduction (receptor)32 | |
| 18q21-22 | BCL2 | Apoptosis14 | NHL,33 DLBL7 |
| 22q12 | SIS/YES2 | Growth factor34 | Atypical NHL35 |
| Chromosomal Region . | Candidate Genes . | Normal Function . | Amplification in Tumorigenesis . |
|---|---|---|---|
| 1q21-23 | IL6R | Signal transduction (receptor)13 | |
| MCL1 | Apoptosis (BCL2 family member)14 | ||
| SKI | Transcription factor15 | ||
| 2p12-16 | REL | Transcription factor16 | DLBL6 |
| 8q24 | MYC | Transcription factor17 | Breast carcinoma,18 Ovarian carcinoma,19FCL20 |
| 9q34 | ABL | Signal transduction (kinase)21 | |
| TAN1 | Signal transduction (receptor)22 | ||
| 12q12-14 | CDK2 | Cell cycle kinase23 | Colorectal carcinoma24 |
| GLI | Transcription factor25 | Gliomas,26Sarcomas27 | |
| SAS | Transmembrane protein28 | Gliomas,29 Sarcomas28 | |
| CDK4 | Cell cycle kinase23 | Gliomas,29 Sarcomas30 | |
| MDM2 | p53 inactivation31 | Gliomas,29Sarcomas30 | |
| 13q32 | — | — | — |
| 16p12 | IL4R | Signal transduction (receptor)32 | |
| 18q21-22 | BCL2 | Apoptosis14 | NHL,33 DLBL7 |
| 22q12 | SIS/YES2 | Growth factor34 | Atypical NHL35 |