Multiplex RT-PCR and Cytogenetic Data on 102 AML Patients
| UPN3-150 . | Status . | Sex . | Age (yr) . | Sample . | Multiplex RT-PCR . | Karyotype . |
|---|---|---|---|---|---|---|
| A | ||||||
| 15 | Presen. | F | 30 | PB | t(8;21)(q22;q22) | 46,XX,t(8;21)(q22;q22)[5] |
| 16 | Presen. | F | 18 | PB | t(8;21)(q22;q22) | 46,XX[1]/47,XX,ins(1)(q11;?),+mar[5] |
| 19 | Presen. | F | 2.5 | BM | t(6;11)(q27;q23) | 46,XX[10] |
| 20 | Presen. | M | 68 | PB | inv(16)(p13;q22) | 46,XY[2]/46,XY,inv(16)(p13q22)[8] |
| 22 | Presen. | M | 9 | PB | t(10;11)(p12;q23) | 46,XY,t(10;11)(q23;q25)[3]/47,XY,ibid,der(19)t(1;19)(q21;p13 or q13)[9] |
| 23 | Relapse | F | 38 | PB | t(6;9)(p23;q34) | 46,XX,t(6;9)(p23;q34)[10] |
| 25 | Relapse | M | 43 | PB | inv(16)(p13;q22) | 46,XY[4]/46,XY,inv(16)(p13q22)[6] |
| 29 | Relapse | M | 73 | PB | t(8;21)(q22;q22) | 46,XY,t(8;21)(q22;q22)[6] |
| 31 | Presen. | M | 64 | PB | dupMLL(11q23) | Failed |
| 43 | Relapse | M | 72 | PB | dupMLL(11q23) | Failed |
| 44 | Presen. | M | 84 | PB | dupMLL(11q23) | 47,XY,+8[3]/48,XY,+8,+18[7] |
| 48 | Presen. | F | 34 | BM | t(9;11)(q22;q23) | 46,XX[4] |
| 62 | Presen. | F | 24 | BM | dupMLL(11q23) | 46,XX[2] |
| 67 | Remis. | M | 52 | PB | dupMLL(11q23) | 46,XY[1]/46,XY,del(9)(q?31)[4] |
| 70 | Remis. | M | 60 | PB | dupMLL(11q23) | 46,XY[10] |
| 73 | Presen. | F | 1.0 | PB | t(10;11)(p12;q23) | 46,X,der(X)t(X;1)(q13;q12),10,der(11)t(10;11)(q22;q23),+mar[11] |
| 75 | Presen. | F | 38 | BM | t(11;19)(q23;p13.1) | 46,XX,[8]/47,XX,+8[2] |
| 84 | Presen. | M | 57 | PB | t(15;17)(q21;q22) | 46,XY[1]/47,XY,+Y[6]/48,XY,+Y,+?21[2] |
| 137 | Presen. | M | 60 | BM | dupMLL(11q23) | Failed |
| 181 | Presen. | F | 40 | PB | t(8;21)(q22;q22) | 46,XX,dup(1)(q21qter),add(14q)[10] |
| 186 | Presen. | M | 41 | PB | t(8;21)(q22;q22) | 46,XY,t(3;3)(q26,q29)[8]/47,XY,idem,+21[2] |
| 192 | Presen. | M | 76 | PB | dupMLL(11q23) | 46,XY[1] |
| 208 | Presen. | F | 66 | PB | t(6;9)(p23;q34) | 46,XX[2] |
| 212 | Relapse | F | 55 | PB | dupMLL(11q23) | 47,XX,+83-150[1] |
| 221 | Presen. | F | 44 | PB | inv(16)(p13;q22) | 46,XX[10] |
| 223 | Presen. | F | 63 | PB | inv(16)(p13;q22) | 46,XX[1] |
| 267 | Presen. | M | 70 | PB | t(15;17)(q21;q22) | 46,XY,t(15;17)(q?22;q11.2)[8] |
| 342 | Presen. | F | 23 | PB | t(15;17)(q21;q22) | 46,XX[10] |
| 10023-151 | Presen. | M | 69 | PB | t(15;17)(q21;q22) | 47,XY,+8[4]/47,XY,+8,del(17)(q?24)[10] |
| 10043-151 | Presen. | M | 65 | PB | t(15;17)(q21;q22) | 46,XY[5] |
| B | ||||||
| 18 | Presen. | M | 2.0 | PB | inv(16)(p13;q22) | ND |
| 118 | Presen. | M | 57 | PB | inv(16)(p13;q22) | ND |
| 119 | Presen. | M | 77 | PB | t(15;17)(q21;q22) | ND |
| 122 | Presen. | F | 41 | PB | t(9;22)(q34;q11) | ND |
| 125 | Presen. | M | 21 | PB | dupMLL(11q23) | ND |
| 128 | Presen. | F | 55 | PB | t(8;21)(q22;q22) | ND |
| 129 | Presen. | M | 21 | BM | dupMLL(11q23) | ND |
| 132 | Presen. | M | 43 | BM | t(8;21)(q22;q22) | ND |
| 145 | Presen. | F | 82 | PB | t(9;22)(q34;q11) | ND |
| 148 | Presen. | F | 59 | PB | t(9;22)(q34;q11) | ND |
| 161 | Presen. | M | 79 | PB | t(15;17)(q21;q22) | ND |
| 172 | Presen. | F | 71 | PB | dupMLL(11q23) | ND |
| 193 | Presen. | F | 55 | PB | t(8;21)(q22;q22) | ND |
| 200 | Presen. | M | 33 | PB | t(6;11)(q27;q23) | ND |
| 240 | Remis. | M | 1.0 | PB | t(2;5)(p23;q35) | ND |
| C | ||||||
| 28 | Presen. | F | 38 | PB | NAD | 46,XX[6] |
| 34 | Presen. | M | 75 | PB | NAD | Failed |
| 36 | Presen. | F | 53 | PB | NAD | 46,XX[10] |
| 39 | Presen. | M | 23 | PB | Ins. N/Q cells | 46,XY,t(15;17)(q22;q21)[10] |
| 45 | Presen. | F | 62 | BM | Ins. N/Q cells | 46,XX[4]/47-48,X,idic(X),+8[cp.6] |
| 46 | Presen. | F | 49 | PB | NAD | 46,XX[10] |
| 47 | Presen. | M | 65 | PB | NAD | 47,XY,+8[10] |
| 51 | Presen. | F | 83 | PB | NAD | 46,XX[7]/48-49,X,−X,+dic(17;17)(p11;p11),+19[cp.3] |
| 53 | Presen. | F | 39 | PB | NAD | 46,XX[10] |
| 54 | Presen. | F | 53 | PB | NAD | 46,XX[10] |
| 55 | Presen. | M | 71 | PB | NAD | 46,XY[8]/48,XY,+8,+18[7] |
| 56 | Relapse | F | 32 | PB | NAD | 46,XX[10] |
| 57 | Presen. | M | 56 | PB | NAD | 45,XY,−7[3] |
| 58 | Presen. | F | 9 | PB | NAD | 46,XX[12]/47,XX,+4[5] |
| 60 | Presen. | F | 43 | PB | NAD | 46,XY[10] |
| 66 | Presen. | F | 78 | PB | NAD | 46,XX[10] |
| 71 | Presen. | F | 49 | PB | NAD | 46,XX,der(21)t(?X;21)(q26;q11.2)[10] |
| 72 | Presen. | F | 65 | PB | NAD | 46,XX[10] |
| 76 | Presen. | F | 70 | PB | NAD | 46,XX[4] |
| 79 | Presen. | M | 69 | PB | NAD | 46,XY[12] |
| 80 | Presen. | F | 48 | PB | NAD | 46,XX[10] |
| 82 | Presen. | F | 55 | PB | NAD | 46,XX[10] |
| 83 | Presen. | F | 53 | PB | NAD | 46,XX[10] |
| 85 | Relapse | M | 71 | BM | NAD | 46,XY[2]/45,XY,−7[7] |
| 86 | Remis. | M | 51 | PB | NAD | 46,XY[6] |
| 144 | Presen. | F | 39 | BM | NAD | 46,XX[8] |
| 146 | Presen. | M | 63 | PB | NAD | 46,XY[10] |
| 150 | Presen. | F | 63 | PB | Ins, N/Q cells | 46,XX[10] |
| 179 | Presen. | M | 63 | PB | NAD | 47,XY,+8[6] |
| 183 | Presen. | M | 74 | PB | NAD | 46,XY[5] |
| 184 | Presen. | M | 42 | BM | NAD | 46,XY[10] |
| 185 | Presen. | M | 73 | PB | NAD | 46,XY[3] |
| 190 | Presen. | M | 75 | PB | NAD | 46,XX[3] 46,XX,5q-[2] |
| 195 | Presen. | F | 68 | PB | NAD | 47,XX,+4[2] |
| 201 | Presen. | M | 48 | PB | NAD | 46,XY[10] |
| 210 | Presen. | M | 47 | PB | NAD | 46,XY[11] |
| D | ||||||
| 30 | Presen. | F | 71 | PB | NAD | ND |
| 33 | Presen. | M | 74 | PB | Ins. N/Q cells | ND |
| 78 | Presen. | M | 78 | BM | NAD | ND |
| 87 | Presen. | M | 76 | PB | NAD | ND |
| 116 | Presen. | F | 38 | PB | NAD | ND |
| 130 | Presen. | F | 72 | PB | NAD | ND |
| 131 | Presen. | F | 38 | BM | NAD | ND |
| 133 | Presen. | F | 35 | PB | Ins. N/Q cells | ND |
| 136 | Presen. | F | 75 | PB | Ins. N/Q cells | ND |
| 140 | Presen. | F | 47 | PB | Ins. N/Q cells | ND |
| 141 | Presen. | F | 82 | BM | NAD | ND |
| 153 | Presen. | F | 36 | PB | NAD | ND |
| 155 | Presen. | M | 78 | PB | NAD | ND |
| 158 | Presen. | F | 80 | BM | Ins. N/Q cells | ND |
| 159 | Presen. | M | 77 | PB | NAD | ND |
| 160 | Presen. | F | 76 | BM | NAD | ND |
| 164 | Presen. | M | 22 | PB | NAD | ND |
| 169 | Presen. | F | 75 | BM | NAD | ND |
| 170 | Presen. | M | 57 | PB | NAD | ND |
| 171 | Presen. | M | 79 | BM | NAD | ND |
| 178 | Presen. | F | 56 | PB | NAD | ND |
| UPN3-150 . | Status . | Sex . | Age (yr) . | Sample . | Multiplex RT-PCR . | Karyotype . |
|---|---|---|---|---|---|---|
| A | ||||||
| 15 | Presen. | F | 30 | PB | t(8;21)(q22;q22) | 46,XX,t(8;21)(q22;q22)[5] |
| 16 | Presen. | F | 18 | PB | t(8;21)(q22;q22) | 46,XX[1]/47,XX,ins(1)(q11;?),+mar[5] |
| 19 | Presen. | F | 2.5 | BM | t(6;11)(q27;q23) | 46,XX[10] |
| 20 | Presen. | M | 68 | PB | inv(16)(p13;q22) | 46,XY[2]/46,XY,inv(16)(p13q22)[8] |
| 22 | Presen. | M | 9 | PB | t(10;11)(p12;q23) | 46,XY,t(10;11)(q23;q25)[3]/47,XY,ibid,der(19)t(1;19)(q21;p13 or q13)[9] |
| 23 | Relapse | F | 38 | PB | t(6;9)(p23;q34) | 46,XX,t(6;9)(p23;q34)[10] |
| 25 | Relapse | M | 43 | PB | inv(16)(p13;q22) | 46,XY[4]/46,XY,inv(16)(p13q22)[6] |
| 29 | Relapse | M | 73 | PB | t(8;21)(q22;q22) | 46,XY,t(8;21)(q22;q22)[6] |
| 31 | Presen. | M | 64 | PB | dupMLL(11q23) | Failed |
| 43 | Relapse | M | 72 | PB | dupMLL(11q23) | Failed |
| 44 | Presen. | M | 84 | PB | dupMLL(11q23) | 47,XY,+8[3]/48,XY,+8,+18[7] |
| 48 | Presen. | F | 34 | BM | t(9;11)(q22;q23) | 46,XX[4] |
| 62 | Presen. | F | 24 | BM | dupMLL(11q23) | 46,XX[2] |
| 67 | Remis. | M | 52 | PB | dupMLL(11q23) | 46,XY[1]/46,XY,del(9)(q?31)[4] |
| 70 | Remis. | M | 60 | PB | dupMLL(11q23) | 46,XY[10] |
| 73 | Presen. | F | 1.0 | PB | t(10;11)(p12;q23) | 46,X,der(X)t(X;1)(q13;q12),10,der(11)t(10;11)(q22;q23),+mar[11] |
| 75 | Presen. | F | 38 | BM | t(11;19)(q23;p13.1) | 46,XX,[8]/47,XX,+8[2] |
| 84 | Presen. | M | 57 | PB | t(15;17)(q21;q22) | 46,XY[1]/47,XY,+Y[6]/48,XY,+Y,+?21[2] |
| 137 | Presen. | M | 60 | BM | dupMLL(11q23) | Failed |
| 181 | Presen. | F | 40 | PB | t(8;21)(q22;q22) | 46,XX,dup(1)(q21qter),add(14q)[10] |
| 186 | Presen. | M | 41 | PB | t(8;21)(q22;q22) | 46,XY,t(3;3)(q26,q29)[8]/47,XY,idem,+21[2] |
| 192 | Presen. | M | 76 | PB | dupMLL(11q23) | 46,XY[1] |
| 208 | Presen. | F | 66 | PB | t(6;9)(p23;q34) | 46,XX[2] |
| 212 | Relapse | F | 55 | PB | dupMLL(11q23) | 47,XX,+83-150[1] |
| 221 | Presen. | F | 44 | PB | inv(16)(p13;q22) | 46,XX[10] |
| 223 | Presen. | F | 63 | PB | inv(16)(p13;q22) | 46,XX[1] |
| 267 | Presen. | M | 70 | PB | t(15;17)(q21;q22) | 46,XY,t(15;17)(q?22;q11.2)[8] |
| 342 | Presen. | F | 23 | PB | t(15;17)(q21;q22) | 46,XX[10] |
| 10023-151 | Presen. | M | 69 | PB | t(15;17)(q21;q22) | 47,XY,+8[4]/47,XY,+8,del(17)(q?24)[10] |
| 10043-151 | Presen. | M | 65 | PB | t(15;17)(q21;q22) | 46,XY[5] |
| B | ||||||
| 18 | Presen. | M | 2.0 | PB | inv(16)(p13;q22) | ND |
| 118 | Presen. | M | 57 | PB | inv(16)(p13;q22) | ND |
| 119 | Presen. | M | 77 | PB | t(15;17)(q21;q22) | ND |
| 122 | Presen. | F | 41 | PB | t(9;22)(q34;q11) | ND |
| 125 | Presen. | M | 21 | PB | dupMLL(11q23) | ND |
| 128 | Presen. | F | 55 | PB | t(8;21)(q22;q22) | ND |
| 129 | Presen. | M | 21 | BM | dupMLL(11q23) | ND |
| 132 | Presen. | M | 43 | BM | t(8;21)(q22;q22) | ND |
| 145 | Presen. | F | 82 | PB | t(9;22)(q34;q11) | ND |
| 148 | Presen. | F | 59 | PB | t(9;22)(q34;q11) | ND |
| 161 | Presen. | M | 79 | PB | t(15;17)(q21;q22) | ND |
| 172 | Presen. | F | 71 | PB | dupMLL(11q23) | ND |
| 193 | Presen. | F | 55 | PB | t(8;21)(q22;q22) | ND |
| 200 | Presen. | M | 33 | PB | t(6;11)(q27;q23) | ND |
| 240 | Remis. | M | 1.0 | PB | t(2;5)(p23;q35) | ND |
| C | ||||||
| 28 | Presen. | F | 38 | PB | NAD | 46,XX[6] |
| 34 | Presen. | M | 75 | PB | NAD | Failed |
| 36 | Presen. | F | 53 | PB | NAD | 46,XX[10] |
| 39 | Presen. | M | 23 | PB | Ins. N/Q cells | 46,XY,t(15;17)(q22;q21)[10] |
| 45 | Presen. | F | 62 | BM | Ins. N/Q cells | 46,XX[4]/47-48,X,idic(X),+8[cp.6] |
| 46 | Presen. | F | 49 | PB | NAD | 46,XX[10] |
| 47 | Presen. | M | 65 | PB | NAD | 47,XY,+8[10] |
| 51 | Presen. | F | 83 | PB | NAD | 46,XX[7]/48-49,X,−X,+dic(17;17)(p11;p11),+19[cp.3] |
| 53 | Presen. | F | 39 | PB | NAD | 46,XX[10] |
| 54 | Presen. | F | 53 | PB | NAD | 46,XX[10] |
| 55 | Presen. | M | 71 | PB | NAD | 46,XY[8]/48,XY,+8,+18[7] |
| 56 | Relapse | F | 32 | PB | NAD | 46,XX[10] |
| 57 | Presen. | M | 56 | PB | NAD | 45,XY,−7[3] |
| 58 | Presen. | F | 9 | PB | NAD | 46,XX[12]/47,XX,+4[5] |
| 60 | Presen. | F | 43 | PB | NAD | 46,XY[10] |
| 66 | Presen. | F | 78 | PB | NAD | 46,XX[10] |
| 71 | Presen. | F | 49 | PB | NAD | 46,XX,der(21)t(?X;21)(q26;q11.2)[10] |
| 72 | Presen. | F | 65 | PB | NAD | 46,XX[10] |
| 76 | Presen. | F | 70 | PB | NAD | 46,XX[4] |
| 79 | Presen. | M | 69 | PB | NAD | 46,XY[12] |
| 80 | Presen. | F | 48 | PB | NAD | 46,XX[10] |
| 82 | Presen. | F | 55 | PB | NAD | 46,XX[10] |
| 83 | Presen. | F | 53 | PB | NAD | 46,XX[10] |
| 85 | Relapse | M | 71 | BM | NAD | 46,XY[2]/45,XY,−7[7] |
| 86 | Remis. | M | 51 | PB | NAD | 46,XY[6] |
| 144 | Presen. | F | 39 | BM | NAD | 46,XX[8] |
| 146 | Presen. | M | 63 | PB | NAD | 46,XY[10] |
| 150 | Presen. | F | 63 | PB | Ins, N/Q cells | 46,XX[10] |
| 179 | Presen. | M | 63 | PB | NAD | 47,XY,+8[6] |
| 183 | Presen. | M | 74 | PB | NAD | 46,XY[5] |
| 184 | Presen. | M | 42 | BM | NAD | 46,XY[10] |
| 185 | Presen. | M | 73 | PB | NAD | 46,XY[3] |
| 190 | Presen. | M | 75 | PB | NAD | 46,XX[3] 46,XX,5q-[2] |
| 195 | Presen. | F | 68 | PB | NAD | 47,XX,+4[2] |
| 201 | Presen. | M | 48 | PB | NAD | 46,XY[10] |
| 210 | Presen. | M | 47 | PB | NAD | 46,XY[11] |
| D | ||||||
| 30 | Presen. | F | 71 | PB | NAD | ND |
| 33 | Presen. | M | 74 | PB | Ins. N/Q cells | ND |
| 78 | Presen. | M | 78 | BM | NAD | ND |
| 87 | Presen. | M | 76 | PB | NAD | ND |
| 116 | Presen. | F | 38 | PB | NAD | ND |
| 130 | Presen. | F | 72 | PB | NAD | ND |
| 131 | Presen. | F | 38 | BM | NAD | ND |
| 133 | Presen. | F | 35 | PB | Ins. N/Q cells | ND |
| 136 | Presen. | F | 75 | PB | Ins. N/Q cells | ND |
| 140 | Presen. | F | 47 | PB | Ins. N/Q cells | ND |
| 141 | Presen. | F | 82 | BM | NAD | ND |
| 153 | Presen. | F | 36 | PB | NAD | ND |
| 155 | Presen. | M | 78 | PB | NAD | ND |
| 158 | Presen. | F | 80 | BM | Ins. N/Q cells | ND |
| 159 | Presen. | M | 77 | PB | NAD | ND |
| 160 | Presen. | F | 76 | BM | NAD | ND |
| 164 | Presen. | M | 22 | PB | NAD | ND |
| 169 | Presen. | F | 75 | BM | NAD | ND |
| 170 | Presen. | M | 57 | PB | NAD | ND |
| 171 | Presen. | M | 79 | BM | NAD | ND |
| 178 | Presen. | F | 56 | PB | NAD | ND |
(A) PCR-positive patients with cytogenetic data; (B) PCR-positive patients with no cytogenetic data; (C) PCR-negative patients with cytogenetic data; (D) PCR-negative patients with no cytogenetic data.
Abbreviations: Presen., presentation; Remis., remission; PB, peripheral blood; BM, bone marrow; NAD, no abnormality detected; Ins. N/Q cells, insufficient number or quality of cells; ND, not done.
Patients for whom both PB and BM samples were analyzed, only 1 has been included in the table.
RNA was purified at Aarhus University Hospital before this study.