Association Between Pretransplant Factors and Mortality After URD Transplantation
| Factor . | Category . | Hazard Ratio . | 95% CI . | PValue . |
|---|---|---|---|---|
| HLA | Match | 1 | ||
| Compatibility | A or B mismatch | 1.0 | 0.4, 2.4 | 1 |
| DRB or DQB mismatch | 2.1 | 1.1, 3.8 | .02 | |
| Multiple mismatch | 3.5 | 1.6, 7.4 | .002 | |
| CMV and | Neither | 2 | 1.1, 3.6 | .02 |
| Fungal | Either | 1 | ||
| Prophylaxis* | Both | 0.6 | 0.3, 1 | .05 |
| Age | >50 yr | 5.3 | 2.1, 13 | <.001 |
| Weight | ≥10% above IBW | 1.8 | 1.1, 3.0 | .02 |
| Disease | ≤1 yr | 1 | ||
| Duration | >1 and ≤3 yr | 0.8 | 0.5, 1.5 | .6 |
| >3 yr | 1.5 | 0.8, 2.8 | .2 | |
| IFN-α | ≥6 m | 2.1 | 1.2, 3.6 | .007 |
| Factor . | Category . | Hazard Ratio . | 95% CI . | PValue . |
|---|---|---|---|---|
| HLA | Match | 1 | ||
| Compatibility | A or B mismatch | 1.0 | 0.4, 2.4 | 1 |
| DRB or DQB mismatch | 2.1 | 1.1, 3.8 | .02 | |
| Multiple mismatch | 3.5 | 1.6, 7.4 | .002 | |
| CMV and | Neither | 2 | 1.1, 3.6 | .02 |
| Fungal | Either | 1 | ||
| Prophylaxis* | Both | 0.6 | 0.3, 1 | .05 |
| Age | >50 yr | 5.3 | 2.1, 13 | <.001 |
| Weight | ≥10% above IBW | 1.8 | 1.1, 3.0 | .02 |
| Disease | ≤1 yr | 1 | ||
| Duration | >1 and ≤3 yr | 0.8 | 0.5, 1.5 | .6 |
| >3 yr | 1.5 | 0.8, 2.8 | .2 | |
| IFN-α | ≥6 m | 2.1 | 1.2, 3.6 | .007 |
*Because of considerable overlap in the introduction of policies for CMV and fungal prophylaxis, the regimens were grouped based on no CMV or fungal prophylaxis (n = 40), CMV or fungal prophylaxis (n = 53: fungal only n = 9, CMV only n = 44), and CMV and fungal prophylaxis (n = 91).