Effect of NAC and IL-2 on the Intracellular Glutathione Level in PBMC of Cancer Patients
| . | A Conventional Chemotherapy . | B IL-2 . | C NAC/IL-2 . | D Healthy Subjects . | Significance Between Groups (P values) . | |
|---|---|---|---|---|---|---|
| A-B . | A-C . | |||||
| n (F/M) | 6 (4/2) | 22 (9/13) | 20 (12/8) | 82 (34/48) | ||
| Age | 56.5 ± 2.5 | 59.7 ± 1.7 | 60.2 ± 2.4 | 57.5 ± 1 | ||
| Total intracellular glutathione (nmol/mg protein) | ||||||
| b | 11.6 ± 1.75 | 12.7 ± 1.2 | 13.5 ± 1.4 | 24.4 ± 1.1 | ||
| t | 10.0 ± 1.58 | 18.9 ± 1.9 | 19.8 ± 1.6 | 24.4 ± 1.1 | <.03 | <.005 |
| P < .01 | P < .005 | |||||
| GSH/GSSG ratio | ||||||
| b | 9.85 ± 2.80 | 8.7 ± 1.4 | 7.8 ± 1.6 | 17.7 ± 1.7 | ||
| t | 4.43 ± 0.93 | 17.5 ± 2.1 | 18.0 ± 2.2 | 17.7 ± 1.7 | <.005 | <.005 |
| P < .005 | P < .001 | |||||
| . | A Conventional Chemotherapy . | B IL-2 . | C NAC/IL-2 . | D Healthy Subjects . | Significance Between Groups (P values) . | |
|---|---|---|---|---|---|---|
| A-B . | A-C . | |||||
| n (F/M) | 6 (4/2) | 22 (9/13) | 20 (12/8) | 82 (34/48) | ||
| Age | 56.5 ± 2.5 | 59.7 ± 1.7 | 60.2 ± 2.4 | 57.5 ± 1 | ||
| Total intracellular glutathione (nmol/mg protein) | ||||||
| b | 11.6 ± 1.75 | 12.7 ± 1.2 | 13.5 ± 1.4 | 24.4 ± 1.1 | ||
| t | 10.0 ± 1.58 | 18.9 ± 1.9 | 19.8 ± 1.6 | 24.4 ± 1.1 | <.03 | <.005 |
| P < .01 | P < .005 | |||||
| GSH/GSSG ratio | ||||||
| b | 9.85 ± 2.80 | 8.7 ± 1.4 | 7.8 ± 1.6 | 17.7 ± 1.7 | ||
| t | 4.43 ± 0.93 | 17.5 ± 2.1 | 18.0 ± 2.2 | 17.7 ± 1.7 | <.005 | <.005 |
| P < .005 | P < .001 | |||||
Bold face indicates values for which significant changes occur.
Abbreviations: b, baseline examination; t, terminal examination.