Peripheral Blood Counts
| Age (wk) . | IL-2 Genotype . | No. . | RBC (106/μL) . | HB (mg/dL) . | HT . | WBC (103/μL) . | Differential Cell Counts (×109/L) . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Segmented Neutrophils . | Lymphocytes . | Monocytes . | Eosinophils . | |||||||
| 3-5 | +/+ | 7 | 6.3 ± 0.6 | 13.6 ± 0.5 | 31 ± 4 | 4.4 ± 1.3 | 0.7 ± 0.4 | 6.6 ± 1.0 | 0.1 ± 0.2 | 0.08 ± 0.02 |
| +/− | 5 | 7.2 ± 1.0 | 12.2 ± 0.6 | 32 ± 3 | 4.9 ± 2.4 | 0.6 ± 0.3 | 7.4 ± 1.8 | 0.2 ± 0.1 | 0.07 ± 0.03 | |
| −/− | 6 | 4.7 ± 0.6 | 10.8 ± 1.5 | 28 ± 5 | 3.8 ± 1.6 | 0.3 ± 0.2* | 7.2 ± 1.2 | 0.1 ± 0.1 | 0.07 ± 0.04 | |
| 6 | +/+ | 5 | 9.2 ± 1.1 | 14 ± 2.3 | 49 ± 2 | 10.4 ± 2.3 | 1.6 ± 0.4 | 8.4 ± 1.4 | 0.3 ± 0.2 | 0.13 ± 0.07 |
| +/− | 4 | 8.9 ± 1.3 | 13 ± 3.1 | 42 ± 4 | 10.1 ± 3.0 | 2.0 ± 0.5 | 7.9 ± 0.9 | 0.2 ± 0.2 | 0.08 ± 0.04 | |
| −/− | 5 | 3.7 ± 2.0 | 7.8 ± 1.0 | 27 ± 3 | 8.8 ± 2.6 | 0.5 ± 0.3† | 8.8 ± 1.3‡ | 0.4 ± 0.3 | 0.12 ± 0.05 | |
| 7 | +/− | 4 | 7.3 ± 0.2 | 10.6 ± 1.4 | 33 ± 1 | 9.4 ± 1.3 | 1.8 ± 0.5 | 9.4 ± 3.2 | 0.2 ± 0.1 | 0.09 ± 0.04 |
| −/− | 4 | 2.5 ± 0.4 | 5.7 ± 0.3 | 11 ± 3 | 9.2 ± 1.2 | 0.4 ± 0.11-153 | 11.3 ± 1.2‡ | 0.2 ± 0.2 | 0.11 ± 0.05 | |
| 8 | +/− | 6 | 7.7 ± 0.2 | 9.8 ± 0.7 | 31 ± 1 | 8.5 ± 1.5 | 1.8 ± 0.6 | 9.8 ± 1.5 | 0.2 ± 0.2 | 0.11 ± 0.03 |
| −/− | 5 | 2.2 ± 0.1 | 4.2 ± 0.3 | 14 ± 4 | 7.7 ± 3.2 | 0.4 ± 0.21-155 | 10.1 ± 2.9‡ | 0.5 ± 0.2 | 0.09 ± 0.02 | |
| 10 | +/− | 4 | 9.8 ± 1.7 | 15.3 ± 1.6 | 33 ± 5 | 12.6 ± 2.3 | 1.6 ± 0.3 | 10.7 ± 3.7 | 0.3 ± 0.2 | 0.19 ± 0.03 |
| −/− | 5 | 2.4 ± 2.2 | 3.9 ± 3.0 | 12 ± 4 | 14.5 ± 2.7 | 0.2 ± 0.3¶ | 11.2 ± 1.8‡ | 0.2 ± 0.2 | 0.15 ± 0.04 | |
| Age (wk) . | IL-2 Genotype . | No. . | RBC (106/μL) . | HB (mg/dL) . | HT . | WBC (103/μL) . | Differential Cell Counts (×109/L) . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Segmented Neutrophils . | Lymphocytes . | Monocytes . | Eosinophils . | |||||||
| 3-5 | +/+ | 7 | 6.3 ± 0.6 | 13.6 ± 0.5 | 31 ± 4 | 4.4 ± 1.3 | 0.7 ± 0.4 | 6.6 ± 1.0 | 0.1 ± 0.2 | 0.08 ± 0.02 |
| +/− | 5 | 7.2 ± 1.0 | 12.2 ± 0.6 | 32 ± 3 | 4.9 ± 2.4 | 0.6 ± 0.3 | 7.4 ± 1.8 | 0.2 ± 0.1 | 0.07 ± 0.03 | |
| −/− | 6 | 4.7 ± 0.6 | 10.8 ± 1.5 | 28 ± 5 | 3.8 ± 1.6 | 0.3 ± 0.2* | 7.2 ± 1.2 | 0.1 ± 0.1 | 0.07 ± 0.04 | |
| 6 | +/+ | 5 | 9.2 ± 1.1 | 14 ± 2.3 | 49 ± 2 | 10.4 ± 2.3 | 1.6 ± 0.4 | 8.4 ± 1.4 | 0.3 ± 0.2 | 0.13 ± 0.07 |
| +/− | 4 | 8.9 ± 1.3 | 13 ± 3.1 | 42 ± 4 | 10.1 ± 3.0 | 2.0 ± 0.5 | 7.9 ± 0.9 | 0.2 ± 0.2 | 0.08 ± 0.04 | |
| −/− | 5 | 3.7 ± 2.0 | 7.8 ± 1.0 | 27 ± 3 | 8.8 ± 2.6 | 0.5 ± 0.3† | 8.8 ± 1.3‡ | 0.4 ± 0.3 | 0.12 ± 0.05 | |
| 7 | +/− | 4 | 7.3 ± 0.2 | 10.6 ± 1.4 | 33 ± 1 | 9.4 ± 1.3 | 1.8 ± 0.5 | 9.4 ± 3.2 | 0.2 ± 0.1 | 0.09 ± 0.04 |
| −/− | 4 | 2.5 ± 0.4 | 5.7 ± 0.3 | 11 ± 3 | 9.2 ± 1.2 | 0.4 ± 0.11-153 | 11.3 ± 1.2‡ | 0.2 ± 0.2 | 0.11 ± 0.05 | |
| 8 | +/− | 6 | 7.7 ± 0.2 | 9.8 ± 0.7 | 31 ± 1 | 8.5 ± 1.5 | 1.8 ± 0.6 | 9.8 ± 1.5 | 0.2 ± 0.2 | 0.11 ± 0.03 |
| −/− | 5 | 2.2 ± 0.1 | 4.2 ± 0.3 | 14 ± 4 | 7.7 ± 3.2 | 0.4 ± 0.21-155 | 10.1 ± 2.9‡ | 0.5 ± 0.2 | 0.09 ± 0.02 | |
| 10 | +/− | 4 | 9.8 ± 1.7 | 15.3 ± 1.6 | 33 ± 5 | 12.6 ± 2.3 | 1.6 ± 0.3 | 10.7 ± 3.7 | 0.3 ± 0.2 | 0.19 ± 0.03 |
| −/− | 5 | 2.4 ± 2.2 | 3.9 ± 3.0 | 12 ± 4 | 14.5 ± 2.7 | 0.2 ± 0.3¶ | 11.2 ± 1.8‡ | 0.2 ± 0.2 | 0.15 ± 0.04 | |
Differential cell counts were performed on blood smears from SPF sex-matched littermates. Data represent the mean ± SD.
Abbreviations: RBC, red blood cells; HB, hemoglobin; HT, hematocrit; WBC, white blood cells.
P < .01.
P < .005.
Cells consisted of atypical blast-like cells that were tartrate sensitive, acid phosphatase-positive, and myeloperoxidase-negative.
P < .005.
P < .001.
P < .001 compared with +/+ littermates.