Table 3. Sequential Analysis of p15... | American Society of Hematology

Table 3.

Sequential Analysis of p15^INK4b Methylation in 10 MDS Cases

	Patient No.
	1	2	3	4	5	6	7	8	9	10
First analysis
FAB type	RAEB	RAEB	RAEB	RAEB-t	RAEB	CMML	RAEB	RAEB	RAEB-t	RAEB
% bone marrow blasts	7	11	8	26	9	4	12	12	23	15
Methylation status	U	U	U	M	U	U	U	M	M	M
Second analysis
Interval between first and second analysis (mo)	17	18	4	4	11	7	11	3	8	14
% Bone marrow blasts	66	35	74	69	67	65	80	35	28	40
Methylation status	M	M	M	M	U	M	M	M	M	M
Third analysis
Interval between second and third analysis (mo)				5			12	2
% bone marrow blasts				41^*			27^*	23^*
Methylation status				M			M	M

	Patient No.
	1	2	3	4	5	6	7	8	9	10
First analysis
FAB type	RAEB	RAEB	RAEB	RAEB-t	RAEB	CMML	RAEB	RAEB	RAEB-t	RAEB
% bone marrow blasts	7	11	8	26	9	4	12	12	23	15
Methylation status	U	U	U	M	U	U	U	M	M	M
Second analysis
Interval between first and second analysis (mo)	17	18	4	4	11	7	11	3	8	14
% Bone marrow blasts	66	35	74	69	67	65	80	35	28	40
Methylation status	M	M	M	M	U	M	M	M	M	M
Third analysis
Interval between second and third analysis (mo)				5			12	2
% bone marrow blasts				41^*			27^*	23^*
Methylation status				M			M	M

Abbreviations: U, unmethylated; M, methylated.

Third analysis performed after intensive chemotherapy, which yielded only transient reduction in the bone marrow blast count.