Clinical Status, Clonal Analysis, and Cytogenetics of 10 Patients With Clonal Hematopoiesis
| Patient No. . | Age (yr) . | BM Ratio at ABMT (MNBC ratio) . | Last BM Ratio Available . | Interval ABMT-Clonal Ratio (mo) . | MDS . | Interval ClonalityMDS (mo) . | Cytogenetics . | Evolution . |
|---|---|---|---|---|---|---|---|---|
| 5 | 46 | 2.1 (NA) | 4.0 | 6 | — | — | 7q− | Mild leukopenia |
| 6 | 54 | 1.5 (1.6) | 3.7 | 24 | — | — | ND | Macrocytic anemia, relapse, lost to follow-up |
| 21 | 46 | 2.0 (1.9) | 7.5 | 13 | — | — | ND | Slight dyserythropoiesis on BM, relapse |
| 23 | 50 | 6.9 (9.6) | 24.3 | 70 | RAEB | 0 | N | Died of complications of MDS |
| 29 | 51 | 3.2 (9.1) | 15.1 | 16 | RA | 13 | 7q− | Severe transfusion-dependent pancytopenia |
| 30 | 49 | 1.4 (NA) | 3.4 | 7 | — | — | ND | Relapse and lost to follow-up |
| 34 | 58 | 4.9 (2.0) | 16.5 | 0 | RA | 15 | 13q− | Severe transfusion-dependent pancytopenia |
| 36 | 34 | 2.1 (NA) | 10.5 | 18 | — | — | N | Died of relapse |
| 42 | 41 | 1.1 (1.1) | 14.0 | 11 | RA | 7 | −7 | Died of complications of MDS |
| 52 | 47 | 6.4 (4.6) | 1.4 | 46 | — | — | 13q− | Severe transfusion-dependent thrombocytopenia, died of relapse |
| Patient No. . | Age (yr) . | BM Ratio at ABMT (MNBC ratio) . | Last BM Ratio Available . | Interval ABMT-Clonal Ratio (mo) . | MDS . | Interval ClonalityMDS (mo) . | Cytogenetics . | Evolution . |
|---|---|---|---|---|---|---|---|---|
| 5 | 46 | 2.1 (NA) | 4.0 | 6 | — | — | 7q− | Mild leukopenia |
| 6 | 54 | 1.5 (1.6) | 3.7 | 24 | — | — | ND | Macrocytic anemia, relapse, lost to follow-up |
| 21 | 46 | 2.0 (1.9) | 7.5 | 13 | — | — | ND | Slight dyserythropoiesis on BM, relapse |
| 23 | 50 | 6.9 (9.6) | 24.3 | 70 | RAEB | 0 | N | Died of complications of MDS |
| 29 | 51 | 3.2 (9.1) | 15.1 | 16 | RA | 13 | 7q− | Severe transfusion-dependent pancytopenia |
| 30 | 49 | 1.4 (NA) | 3.4 | 7 | — | — | ND | Relapse and lost to follow-up |
| 34 | 58 | 4.9 (2.0) | 16.5 | 0 | RA | 15 | 13q− | Severe transfusion-dependent pancytopenia |
| 36 | 34 | 2.1 (NA) | 10.5 | 18 | — | — | N | Died of relapse |
| 42 | 41 | 1.1 (1.1) | 14.0 | 11 | RA | 7 | −7 | Died of complications of MDS |
| 52 | 47 | 6.4 (4.6) | 1.4 | 46 | — | — | 13q− | Severe transfusion-dependent thrombocytopenia, died of relapse |
Abbreviations: RA, refractory anemia; RAEB, refractory anemia with excess of blasts; ND, not done; N, normal; NA, not available.