Table 2.

Percentage of PNH Cells at Different Stages of Maturation

Patient Neutrophils CD34+/CD38+Cells CD34+/CD38 Cells
PNH043 
 Pre  96  50  0  
 Post  94  87  91 
PNH042  
 Pre  97  29  7  
 Post  96  90 88  
PNH056  
 Pre  50  47  0  
 Post  55 68  51  
PNH046  
 Pre  79  78  71  
 Post 76  80  73 
Patient Neutrophils CD34+/CD38+Cells CD34+/CD38 Cells
PNH043 
 Pre  96  50  0  
 Post  94  87  91 
PNH042  
 Pre  97  29  7  
 Post  96  90 88  
PNH056  
 Pre  50  47  0  
 Post  55 68  51  
PNH046  
 Pre  79  78  71  
 Post 76  80  73 

The figures represent the percentage of peripheral blood cells in each subgroup that are of PNH phenotype as defined by lack of CD59 expression. CD34+/CD38+ cells are more mature stem cells while CD34+/CD38 cells are more primitive. The results for steady-state blood (pre–G-CSF) and mobilized blood (post–G-CSF) are shown.

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