Hematologic Parameters in ζ− Null and ζ−/α1− Compound Heterozygote Mice
| Mice 129/BL Swiss . | Genotype . | Hgb g/dL . | MCV fL . | MCH pg . | Platelets × 106/mL . |
|---|---|---|---|---|---|
| Wild-type (N = 7) | ζα1α2/ζα1α2 | 15.7 (0.5) | 52.3 (0.9) | 17.4 (0.9) | 1219 (115) |
| ζ Heterozygote (N = 5) | ζ−α1α2/ζα1α2 | 13.5 (1.0) | 47.0 (3) | 15.1 (1.4) | 1116 (224) |
| ζ Homozygote (N = 5) | ζ−α1α2/ζ−α1α2 | 10.1 (0.7) | 41.8 (1) | 13.2 (0.8) | 3820 (712) |
| Compound α−/ζ− heterozygote (N = 3) | ζ−α1α2/ζα1−α2 | 10.3 (1.0) | 41.6 (1) | 14.9 (0.2) | 4933 (832) |
| Mice 129/BL Swiss . | Genotype . | Hgb g/dL . | MCV fL . | MCH pg . | Platelets × 106/mL . |
|---|---|---|---|---|---|
| Wild-type (N = 7) | ζα1α2/ζα1α2 | 15.7 (0.5) | 52.3 (0.9) | 17.4 (0.9) | 1219 (115) |
| ζ Heterozygote (N = 5) | ζ−α1α2/ζα1α2 | 13.5 (1.0) | 47.0 (3) | 15.1 (1.4) | 1116 (224) |
| ζ Homozygote (N = 5) | ζ−α1α2/ζ−α1α2 | 10.1 (0.7) | 41.8 (1) | 13.2 (0.8) | 3820 (712) |
| Compound α−/ζ− heterozygote (N = 3) | ζ−α1α2/ζα1−α2 | 10.3 (1.0) | 41.6 (1) | 14.9 (0.2) | 4933 (832) |
Abbreviations: Hb, hemoglobin concentration (g/dL); MCV, mean corpuscular volume ( μ3/red cell); MCH, mean corpuscular hemoglobin (Hb pg/red cell); N, number of mice.