Multivariable Analysis of Risk Factors for Relapse
| . | Risk Factor . | RR . | 95% CI . | P Value . |
|---|---|---|---|---|
| Model 1 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 4.8 | 1.0-22.7 | .046 | |
| Remission Status | ||||
| Remission | 1.0 | — | — | |
| Relapse | 2.0 | 0.6-6.6 | .249 | |
| Model 2 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 6.9 | 1.5-32.9 | .014 | |
| Donor Type | ||||
| Matched-related | 1.0 | — | — | |
| URD, mismatch | 0.3 | 0.1-1.0 | .058 | |
| Model 3 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 5.8 | 1.3-26.6 | .023 | |
| GVHD | ||||
| Grades 0-I (or Auto) | 1.0 | — | — | |
| Grades ≥ II | 0.6 | 0.2-2.0 | .410 | |
| Model 4 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 5.5 | 1.2-25.4 | .028 | |
| TBI | ||||
| >1200 cGy | 1.0 | — | — | |
| Chemo or ≤1,200 | 4.3 | 1.3-13.8 | .015 |
| . | Risk Factor . | RR . | 95% CI . | P Value . |
|---|---|---|---|---|
| Model 1 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 4.8 | 1.0-22.7 | .046 | |
| Remission Status | ||||
| Remission | 1.0 | — | — | |
| Relapse | 2.0 | 0.6-6.6 | .249 | |
| Model 2 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 6.9 | 1.5-32.9 | .014 | |
| Donor Type | ||||
| Matched-related | 1.0 | — | — | |
| URD, mismatch | 0.3 | 0.1-1.0 | .058 | |
| Model 3 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 5.8 | 1.3-26.6 | .023 | |
| GVHD | ||||
| Grades 0-I (or Auto) | 1.0 | — | — | |
| Grades ≥ II | 0.6 | 0.2-2.0 | .410 | |
| Model 4 | PCR Status | |||
| PCR-negative | 1.0 | — | — | |
| PCR-positive | 5.5 | 1.2-25.4 | .028 | |
| TBI | ||||
| >1200 cGy | 1.0 | — | — | |
| Chemo or ≤1,200 | 4.3 | 1.3-13.8 | .015 |
Four multivariable models examining the effect of the PCR test for bcr-abl while controlling for other clinical variables. In each model the relative risk (RR) of relapse compares PCR-positive to PCR-negative patients. In addition, clinical variables are added separately to the model containing the PCR status of the patient. For the variable of remission status at the time of BMT, relapse is compared to remission; for donor type, unrelated or partially matched v matched, syngeneic, and autologous; for GVHD, grades II-IV acute GVHD v grades O-I; and for conditioning regimen, patients receiving chemotherapy only or TBI-containing regimens with ≤1,200 cGy v TBI-containing regimens with >1,200 cGy.