Table 2. Mast Cell Development Induced... | American Society of Hematology

Table 2.

Mast Cell Development Induced by IL-6 and TNF- α From Different Strains of Mice

Strain	Cytokine^* (10 ng/mL)	Mast Cells/Culture (10⁴ ± SD)	Histamine/Culture (μg ± SD)
C3H/HeN	None	2.1 ± 0.6	0.0227 ± 0.0036
	rIL-6	83.3 ± 8.5	0.4074 ± 0.0314^†
	rTNF-α	113.3 ± 31.6	0.3846 ± 0.0125^†
BALB/c	None	24.1 ± 4.1	0.0496 ± 0.0104
	rIL-6	73.3 ± 11.4	0.2008 ± 0.0192^†
	rTNF-α	60.8 ± 9.2	0.1100 ± 0.0096^‡
BALB/c nu/nu	None	0	0
	rIL-6	0	0
	rTNF-α	0	0
WBB6F₁ +/+	None	18.7 ± 7.1	0.0833 ± 0.0017
	rIL-6	65.0 ± 2.7	0.1887 ± 0.0179^†
	rTNF-α	102.5 ± 14.1	0.3333 ± 0.0454^†
WBB6F₁ W/W^V	None	9.1 ± 4.2	0.0505 ± 0.0246
	rIL-6	53.7 ± 14.7	0.2329 ± 0.0239^†
	rTNF-α	71.6 ± 7.2	0.3810 ± 0.0208^†

Strain	Cytokine^* (10 ng/mL)	Mast Cells/Culture (10⁴ ± SD)	Histamine/Culture (μg ± SD)
C3H/HeN	None	2.1 ± 0.6	0.0227 ± 0.0036
	rIL-6	83.3 ± 8.5	0.4074 ± 0.0314^†
	rTNF-α	113.3 ± 31.6	0.3846 ± 0.0125^†
BALB/c	None	24.1 ± 4.1	0.0496 ± 0.0104
	rIL-6	73.3 ± 11.4	0.2008 ± 0.0192^†
	rTNF-α	60.8 ± 9.2	0.1100 ± 0.0096^‡
BALB/c nu/nu	None	0	0
	rIL-6	0	0
	rTNF-α	0	0
WBB6F₁ +/+	None	18.7 ± 7.1	0.0833 ± 0.0017
	rIL-6	65.0 ± 2.7	0.1887 ± 0.0179^†
	rTNF-α	102.5 ± 14.1	0.3333 ± 0.0454^†
WBB6F₁ W/W^V	None	9.1 ± 4.2	0.0505 ± 0.0246
	rIL-6	53.7 ± 14.7	0.2329 ± 0.0239^†
	rTNF-α	71.6 ± 7.2	0.3810 ± 0.0208^†

Mouse spleen cells were cultured with complete culture medium. Cytokines were added at the start of the cultures. Mast cell number and histamine quantity per culture were determined on day 12.

†

P < .01.

‡

P < .05 compared with data without adding cytokines.

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