Survival of LTRA 24 Hours After 5-FU and KL as Measured in the Competitive Repopulation Assay
| Treatment . | No. of Weekly Cycles . | RU/Hind Limb . | % of Control . |
|---|---|---|---|
| Saline | 2 | 127 | 100 |
| 5-FU alone | 2 | 106 | 84 |
| 5-FU + KL | 2 | 20 | 16 |
| 5-FU + KL + G-CSF | 2 | 17 | 14 |
| Treatment . | No. of Weekly Cycles . | RU/Hind Limb . | % of Control . |
|---|---|---|---|
| Saline | 2 | 127 | 100 |
| 5-FU alone | 2 | 106 | 84 |
| 5-FU + KL | 2 | 20 | 16 |
| 5-FU + KL + G-CSF | 2 | 17 | 14 |
Repopulation units were calculated from chimerism in lethally irradiated recipients at 8 months after transplantation of BM cells from treated BM mixed with a constant number of untreated BM. The repopulation units (RU) were calculated according to the formula: RU = (% of Gpi-1b * C)/(100-% of Gpi-1b), where C is the number of RU in control (Gpi-1a) marrow and 1 RU is defined as the repopulating ability of 105 normal BM cells.29