Engraftment After 5-FU/KL Ablation
| Treatment . | No. of Weekly Cycles . | % Gpi-1a Engraftment (PB) . | |||
|---|---|---|---|---|---|
| . | . | 1 mo . | 3 mo . | 6 mo . | 8 mo . |
| Three injections of 107 BM cells: | |||||
| Saline | 2 | 3.4 ± 0.9 (15)‡ | 12.6 ± 0.9 (14) | 12.4 ± 2.1 (15) | 17.8 ± 1.7 (15) |
| 5-FU | 1 | 26.7 ± 2.5 (5) | 10.9 ± 2.1 (5) | 14.4 ± 1.7 (5) | 15.0 ± 1.5 (5) |
| 5-FU | 2 | 44.8 ± 3.3 (13) | 27.1 ± 4.8 (12) | 17.7 ± 3.0 (15) | 18.5 ± 2.6 (15) |
| 5-FU + KL* | 1 | 39.0 ± 3.4 (10) | 20.2 ± 2.1 (10) | 16.8 ± 1.6 (10) | 13.5 ± 1.0 (10) |
| 5-FU + KL (12.5 μg/kg) | 2 | 38.1 ± 5.6 (10) | 22.7 ± 6.2 (10) | 21.8 ± 2.1 (10) | 19.7 ± 2.1 (10) |
| 5-FU + KL* | 2 | 55.0 ± 3.2 (18) | 39.9 ± 4.4 (18) | 32.3 ± 2.9 (18) | 33.0 ± 2.7 (18) |
| 5-FU + KL + G-CSF† | 2 | 57.8 ± 2.5 (9) | 40.7 ± 2.3 (9) | 28.2 ± 2.8 (9) | 29.7 ± 3.0 (9) |
| One injection of 107 BM cells: | |||||
| 5-FU | 1 | 17.7 ± 1.9 (5) | 5.4 ± 1.0 (5) | 12.2 ± 0.6 (5) | 6.5 ± 0.6 (5) |
| 5-FU | 2 | 21.6 ± 2.4 (5) | 2.2 ± 1.7 (5) | 9.6 ± 1.4 (5) | 9.8 ± 1.2 (5) |
| 5-FU + KL* | 2 | 46.2 ± 3.9 (10) | 22.7 ± 3.9 (10) | 21.6 ± 2.9 (10) | 15.0 ± 2.5 (10) |
| One injection of 3 × 107 BM cells: | |||||
| 5-FU + KL* | 2 | 60.2 ± 1.3 (5) | 51.2 ± 3.0 (5) | 28.6 ± 3.9 (5) | 30.5 ± 1.5 (5) |
| Treatment . | No. of Weekly Cycles . | % Gpi-1a Engraftment (PB) . | |||
|---|---|---|---|---|---|
| . | . | 1 mo . | 3 mo . | 6 mo . | 8 mo . |
| Three injections of 107 BM cells: | |||||
| Saline | 2 | 3.4 ± 0.9 (15)‡ | 12.6 ± 0.9 (14) | 12.4 ± 2.1 (15) | 17.8 ± 1.7 (15) |
| 5-FU | 1 | 26.7 ± 2.5 (5) | 10.9 ± 2.1 (5) | 14.4 ± 1.7 (5) | 15.0 ± 1.5 (5) |
| 5-FU | 2 | 44.8 ± 3.3 (13) | 27.1 ± 4.8 (12) | 17.7 ± 3.0 (15) | 18.5 ± 2.6 (15) |
| 5-FU + KL* | 1 | 39.0 ± 3.4 (10) | 20.2 ± 2.1 (10) | 16.8 ± 1.6 (10) | 13.5 ± 1.0 (10) |
| 5-FU + KL (12.5 μg/kg) | 2 | 38.1 ± 5.6 (10) | 22.7 ± 6.2 (10) | 21.8 ± 2.1 (10) | 19.7 ± 2.1 (10) |
| 5-FU + KL* | 2 | 55.0 ± 3.2 (18) | 39.9 ± 4.4 (18) | 32.3 ± 2.9 (18) | 33.0 ± 2.7 (18) |
| 5-FU + KL + G-CSF† | 2 | 57.8 ± 2.5 (9) | 40.7 ± 2.3 (9) | 28.2 ± 2.8 (9) | 29.7 ± 3.0 (9) |
| One injection of 107 BM cells: | |||||
| 5-FU | 1 | 17.7 ± 1.9 (5) | 5.4 ± 1.0 (5) | 12.2 ± 0.6 (5) | 6.5 ± 0.6 (5) |
| 5-FU | 2 | 21.6 ± 2.4 (5) | 2.2 ± 1.7 (5) | 9.6 ± 1.4 (5) | 9.8 ± 1.2 (5) |
| 5-FU + KL* | 2 | 46.2 ± 3.9 (10) | 22.7 ± 3.9 (10) | 21.6 ± 2.9 (10) | 15.0 ± 2.5 (10) |
| One injection of 3 × 107 BM cells: | |||||
| 5-FU + KL* | 2 | 60.2 ± 1.3 (5) | 51.2 ± 3.0 (5) | 28.6 ± 3.9 (5) | 30.5 ± 1.5 (5) |