Results for metaphases analyzed by conventional cytogenetics and by metaphase FISH for 154 patients
Parameter . | Patients, n (%) . |
|---|---|
| Overall Results | |
| Abnormal cytogenetics and/or metaphase FISH | 61 (40) |
| Abnormal cytogenetics | 43 (28) |
| Abnormal metaphase FISH | 46 (30) |
| Cytogenetics versus metaphase FISH | |
| Normal cytogenetics and normal metaphase FISH | 41 (27) |
| Abnormal cytogenetics and normal metaphase FISH | 4 (3) |
| Normal cytogenetics and abnormal metaphase FISH | 18 (12) |
| Abnormal cytogenetics and abnormal metaphase FISH | 28 (18) |
| Normal cytogenetics and incomplete metaphase FISH* | 52 (34) |
| Abnormal cytogenetics and incomplete metaphase FISH* | 11 (7) |
| Detection of common chromosome anomalies in myeloma | |
| t(11;14) detected by cytogenetics and/or metaphase FISH for IGH/CCND1 | 12 (7.8) |
| t(4;14) detected by cytogenetics and/or metaphase FISH for IGH/FGFR3 | 10 (6.5) |
| t(14;16) detected by cytogenetics and/or metaphase FISH for IGH/MAF | 3 (1.9) |
| Metaphase FISH detected loss of D13S319 and LAMP1, or loss of D13S319 | 23 (14.9) |
| Metaphase FISH detected fewer than CCND1 signals | 20 (13.0) |
| Metaphase FISH detect absence of p53 | 9 (5.8) |
Parameter . | Patients, n (%) . |
|---|---|
| Overall Results | |
| Abnormal cytogenetics and/or metaphase FISH | 61 (40) |
| Abnormal cytogenetics | 43 (28) |
| Abnormal metaphase FISH | 46 (30) |
| Cytogenetics versus metaphase FISH | |
| Normal cytogenetics and normal metaphase FISH | 41 (27) |
| Abnormal cytogenetics and normal metaphase FISH | 4 (3) |
| Normal cytogenetics and abnormal metaphase FISH | 18 (12) |
| Abnormal cytogenetics and abnormal metaphase FISH | 28 (18) |
| Normal cytogenetics and incomplete metaphase FISH* | 52 (34) |
| Abnormal cytogenetics and incomplete metaphase FISH* | 11 (7) |
| Detection of common chromosome anomalies in myeloma | |
| t(11;14) detected by cytogenetics and/or metaphase FISH for IGH/CCND1 | 12 (7.8) |
| t(4;14) detected by cytogenetics and/or metaphase FISH for IGH/FGFR3 | 10 (6.5) |
| t(14;16) detected by cytogenetics and/or metaphase FISH for IGH/MAF | 3 (1.9) |
| Metaphase FISH detected loss of D13S319 and LAMP1, or loss of D13S319 | 23 (14.9) |
| Metaphase FISH detected fewer than CCND1 signals | 20 (13.0) |
| Metaphase FISH detect absence of p53 | 9 (5.8) |
Incomplete indicates fewer than 9 metaphases were found to analyze with 1 or more FISH probes