Correlation between in vitro intrinsic resistance to tipifarnib and resistance to other cytotoxic drugs in untreated pediatric AML and ALL samples
. | Median LC50 value, μg/mL (p25-p75) . | Spearman ρ* . | P . | No. . |
|---|---|---|---|---|
| AML | ||||
| Tipifarnib | 3.1 (1.58-5.45) | — | — | 52 |
| Daunorubicin | 0.17 (0.10-0.30) | 0.62 | < .001 | 50 |
| Etoposide | 2.99 (1.64-8.0) | 0.53 | < .001 | 49 |
| Cytarabine | 0.37 (0.13-0.67) | 0.36 | .01 | 50 |
| 6-Thioguanine | 5.0 (2.94-7.65) | 0.32 | .03 | 49 |
| ALL | ||||
| Tipifarnib | 4.8 (1.87-10.4) | — | — | 36 |
| Prednisolone | 0.32 (0.05-6.2) | –0.35 | .05 | 32 |
| Vincristine | 0.70 (0.13-6.7) | 0.009 | .96 | 32 |
| l-Asparaginase | 0.14 (0.03-0.94) | 0.003 | .99 | 32 |
. | Median LC50 value, μg/mL (p25-p75) . | Spearman ρ* . | P . | No. . |
|---|---|---|---|---|
| AML | ||||
| Tipifarnib | 3.1 (1.58-5.45) | — | — | 52 |
| Daunorubicin | 0.17 (0.10-0.30) | 0.62 | < .001 | 50 |
| Etoposide | 2.99 (1.64-8.0) | 0.53 | < .001 | 49 |
| Cytarabine | 0.37 (0.13-0.67) | 0.36 | .01 | 50 |
| 6-Thioguanine | 5.0 (2.94-7.65) | 0.32 | .03 | 49 |
| ALL | ||||
| Tipifarnib | 4.8 (1.87-10.4) | — | — | 36 |
| Prednisolone | 0.32 (0.05-6.2) | –0.35 | .05 | 32 |
| Vincristine | 0.70 (0.13-6.7) | 0.009 | .96 | 32 |
| l-Asparaginase | 0.14 (0.03-0.94) | 0.003 | .99 | 32 |
— indicates not analyzed.
Spearman ρ correlation coefficient for the correlation between tipifarnib resistance and resistance to the other tested drug