Table 6.

Homologous subsets

Light chain
Heavy chain
IGKV
IGKJ
HOM
KCDR3
IGHV
IGHD
IGHJ
HOM
HCDR3
Set 1          
   P1422   IGKV2-30   IGKJ2   95, 7   MQGTHW PYT   IGHV4-34   IGHD5-12   IGHJ6   91, 9   ARGYADTPTFRRYYYYGMDV  
   P103   IGKV2-30   IGKJ2   97, 3   ------P---   IGHV4-34   IGHD3-10   IGHJ6   95, 9   ----P---VV----------  
   P907   IGKV2-30   IGKJ2   97   ----Y- ---   IGHV4-34   IGHD4-17   IGHJ6   93, 2   ----GTSA-TK---------  
   P1626   IGKV2-30   IGKJ2   96, 2   ------ ---   IGHV4-34   IGHD4-17   IGHJ6   94, 8   -S-S ---T----------  
   P1939   IGKV2-30   IGKJ2   96   -------G--   IGHV4-34   IGHD5-5   IGHJ6   94, 5   V---P--AVVK-------E-  
   P711   IGKV2-30   IGKJ2   99, 3   ------ ---   IGHV4-34   IGHD6-19   IGHJ4   97, 4   ARGQWLDNY  
   P860   IGKV2-30   IGKJ2   96, 3   ------ ---   IGHV4-30-4   IGHD4-23   IGHJ5   91   VRDGNSN  
Set 2a          
   P1986   IGKV1-39/1D-39   IGKJ2   100   QQSYSTPPYT   IGHV1-8   IGHD6-13   IGHJ6   100   ARGLLSPYSSSWYWDFRHYYYGMDV  
   N1457   IGKV1-39/1D-39   IGKJ2   100   ----------   IGHV1-18   IGHD6-19   IGHJ4   99, 3   ARKQWLPQYYFDY  
   P439   IGKV1-39/1D-39   IGKJ2   100   ----------   IGHV1-3   IGHD6-19   IGHJ4   100   --W---VLG----  
Set 2b          
   P1114   IGKV1-39/1D-39   IGKJ4   100   QQSYSTPLT   IGHV4-39   IGHD6-13   IGHJ5   100   ARRTGYSSSWYSTYNWFDP  
   P1615   IGKV1-39/1D-39   IGKJ1   100   -------P-   IGHV4-39   IGHD6-13   IGHJ5   100   -S-R------FNV-A----  
   P191   IGKV1-39/1D-39   IGKJ4   100   ---------   IGHV3-49   IGHD3-3   IGHJ4   100   TRGPAEEYYDFWSGYYRLGGYY  
   N235   IGKV1-39/1D-39   IGKJ4   99, 6   ---------   IGHV3-74   IGHD3-9   IGHJ4   100   ARDLSGHYDILTGYYREIFDY  
Set 3          
   N31   IGKV1-5   IGKJ1   100   QQYNSYPWT   IGHV4-39   IGHD3-16   IGHJ3   100   ARTLSYYDYVWANAFDI  
   N232   IGKV1-5   IGKJ1   100   ---------   IGHV3-30   IGHD2-15   IGHJ6   100   AKDSVSVVVVAATYLTPYYYYGMDV  
   N1622   IGKV1-5   IGKJ1   100   ---------   IGHV4-39   IGHD2-8   IGHJ6   100   ARGCRCTNGVCYVYYYYGMDV  
   P1289   IGKV1-5   IGKJ3   96, 4   -------F-   IGHV4-59   IGHD5-24   IGHJ3   87   GRGGNGYNYIQI  
Set 4          
   P1531   IGLV3-21   IGLJ2/3   98, 3   QVWDSGSDHPWV   IGHV3-21   ND   IGHJ6   97, 3   ARDANGMDV  
   P1321   IGLV3-21   IGLJ2/3   99   ------------   IGHV3-21   IGHD1-1   IGHJ6   98, 6   ---Q-A---  
   P326   IGLV3-21   IGLJ2/3   99, 7   -----S------   IGHV3-21   IGHD1-14   IGHJ6   98, 6   -I-R-----  
   P173   IGLV3-21   IGLJ2/3   100   ------------   IGHV3-21   IGHD3-10   IGHJ4   99   AREPLSVLLWFGESFGGGFDY  
   P458   IGLV3-21   IGLJ2/3   98   ------------   IGHV3-11   IGHD5-24   IGHJ4   97, 7   ARDRGQQPFDY  
   P786   IGLV3-21   IGLJ2/3   99   ------------   IGHV3-23   IGHD3-22   IGHJ4   97   AKDWRGESYYDSSGCIDY  
   N1533   IGLV3-21   IGLJ2/3   100   -----S----V-   IGHV1-69   IGHD3-22   IGHJ4   100   AYYYYDSSGYFRY  
   P1132   IGLV3-21   IGLJ2/3   99   -----S------   IGHV4-39   IGHD3-22   IGHJ4   98, 3   ARAPHDSSGYDAYVWDY  
   N1707   IGLV3-21   IGLJ2/3   98, 9   -----S------   IGHV3-23   IGHD3-22   IGHJ1   96, 2   AKDYDSSGANFQH  
Set 5          
   P460   IGKLV1-44   IGLJ2/3   99   AAWDDSLNGPV   IGHV4-b   IGHD6-13   IGHJ5   97, 3   ARIRWGSSWYDCFDP  
   P1558
 		 IGKLV1-44
 		 IGLJ2/3
 		 100
 		 ---------Q-
 		 IGHV4-b
 		 IGHD6-19
 		 IGHJ4
 		 100
 		 --A-YS-V---Y--Y
 
Light chain
Heavy chain
IGKV
IGKJ
HOM
KCDR3
IGHV
IGHD
IGHJ
HOM
HCDR3
Set 1          
   P1422   IGKV2-30   IGKJ2   95, 7   MQGTHW PYT   IGHV4-34   IGHD5-12   IGHJ6   91, 9   ARGYADTPTFRRYYYYGMDV  
   P103   IGKV2-30   IGKJ2   97, 3   ------P---   IGHV4-34   IGHD3-10   IGHJ6   95, 9   ----P---VV----------  
   P907   IGKV2-30   IGKJ2   97   ----Y- ---   IGHV4-34   IGHD4-17   IGHJ6   93, 2   ----GTSA-TK---------  
   P1626   IGKV2-30   IGKJ2   96, 2   ------ ---   IGHV4-34   IGHD4-17   IGHJ6   94, 8   -S-S ---T----------  
   P1939   IGKV2-30   IGKJ2   96   -------G--   IGHV4-34   IGHD5-5   IGHJ6   94, 5   V---P--AVVK-------E-  
   P711   IGKV2-30   IGKJ2   99, 3   ------ ---   IGHV4-34   IGHD6-19   IGHJ4   97, 4   ARGQWLDNY  
   P860   IGKV2-30   IGKJ2   96, 3   ------ ---   IGHV4-30-4   IGHD4-23   IGHJ5   91   VRDGNSN  
Set 2a          
   P1986   IGKV1-39/1D-39   IGKJ2   100   QQSYSTPPYT   IGHV1-8   IGHD6-13   IGHJ6   100   ARGLLSPYSSSWYWDFRHYYYGMDV  
   N1457   IGKV1-39/1D-39   IGKJ2   100   ----------   IGHV1-18   IGHD6-19   IGHJ4   99, 3   ARKQWLPQYYFDY  
   P439   IGKV1-39/1D-39   IGKJ2   100   ----------   IGHV1-3   IGHD6-19   IGHJ4   100   --W---VLG----  
Set 2b          
   P1114   IGKV1-39/1D-39   IGKJ4   100   QQSYSTPLT   IGHV4-39   IGHD6-13   IGHJ5   100   ARRTGYSSSWYSTYNWFDP  
   P1615   IGKV1-39/1D-39   IGKJ1   100   -------P-   IGHV4-39   IGHD6-13   IGHJ5   100   -S-R------FNV-A----  
   P191   IGKV1-39/1D-39   IGKJ4   100   ---------   IGHV3-49   IGHD3-3   IGHJ4   100   TRGPAEEYYDFWSGYYRLGGYY  
   N235   IGKV1-39/1D-39   IGKJ4   99, 6   ---------   IGHV3-74   IGHD3-9   IGHJ4   100   ARDLSGHYDILTGYYREIFDY  
Set 3          
   N31   IGKV1-5   IGKJ1   100   QQYNSYPWT   IGHV4-39   IGHD3-16   IGHJ3   100   ARTLSYYDYVWANAFDI  
   N232   IGKV1-5   IGKJ1   100   ---------   IGHV3-30   IGHD2-15   IGHJ6   100   AKDSVSVVVVAATYLTPYYYYGMDV  
   N1622   IGKV1-5   IGKJ1   100   ---------   IGHV4-39   IGHD2-8   IGHJ6   100   ARGCRCTNGVCYVYYYYGMDV  
   P1289   IGKV1-5   IGKJ3   96, 4   -------F-   IGHV4-59   IGHD5-24   IGHJ3   87   GRGGNGYNYIQI  
Set 4          
   P1531   IGLV3-21   IGLJ2/3   98, 3   QVWDSGSDHPWV   IGHV3-21   ND   IGHJ6   97, 3   ARDANGMDV  
   P1321   IGLV3-21   IGLJ2/3   99   ------------   IGHV3-21   IGHD1-1   IGHJ6   98, 6   ---Q-A---  
   P326   IGLV3-21   IGLJ2/3   99, 7   -----S------   IGHV3-21   IGHD1-14   IGHJ6   98, 6   -I-R-----  
   P173   IGLV3-21   IGLJ2/3   100   ------------   IGHV3-21   IGHD3-10   IGHJ4   99   AREPLSVLLWFGESFGGGFDY  
   P458   IGLV3-21   IGLJ2/3   98   ------------   IGHV3-11   IGHD5-24   IGHJ4   97, 7   ARDRGQQPFDY  
   P786   IGLV3-21   IGLJ2/3   99   ------------   IGHV3-23   IGHD3-22   IGHJ4   97   AKDWRGESYYDSSGCIDY  
   N1533   IGLV3-21   IGLJ2/3   100   -----S----V-   IGHV1-69   IGHD3-22   IGHJ4   100   AYYYYDSSGYFRY  
   P1132   IGLV3-21   IGLJ2/3   99   -----S------   IGHV4-39   IGHD3-22   IGHJ4   98, 3   ARAPHDSSGYDAYVWDY  
   N1707   IGLV3-21   IGLJ2/3   98, 9   -----S------   IGHV3-23   IGHD3-22   IGHJ1   96, 2   AKDYDSSGANFQH  
Set 5          
   P460   IGKLV1-44   IGLJ2/3   99   AAWDDSLNGPV   IGHV4-b   IGHD6-13   IGHJ5   97, 3   ARIRWGSSWYDCFDP  
   P1558
 		 IGKLV1-44
 		 IGLJ2/3
 		 100
 		 ---------Q-
 		 IGHV4-b
 		 IGHD6-19
 		 IGHJ4
 		 100
 		 --A-YS-V---Y--Y
 

Subset 1 has been reported previously in Messmer et al35 ; subset 2b has been reported previously in Ghiotto et al33  and Tobin et al36 ; and subset 4 has been reported previously in Tobin et al25  and Ghia et al.26  Subsets 2b, 3, and 5 are novel.

HOM indicates homology to germ line.

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