Effect of MDM2 inhibitor in primary AML and p53 status of the blasts
. | . | Annexin V+ in CD34+ fraction, % (in total MNC, %) . | . | . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient no. . | CD34+, % . | DMSO* . | 1 μM* . | 5 μM* . | 10 μM* . | Cell number reduction, %† . | p53 status . | |||
| 1 | 68 | 22 (27) | 36 (41) | 65 (67) | 84 (82) | 77 | Wild-type | |||
| 2 | 96 | 9 (11) | 49 (52) | 81 (82) | 87 (87) | 94 | Wild-type | |||
| 3 | 93 | 8 (11) | 31 (32) | 44 (47) | 76 (74) | 70 | Wild-type | |||
| 4 | 79 | 17 (19) | 39 (39) | 76 (66) | 91 (84) | 91 | Wild-type | |||
| 5 | 92 | 33 (32) | 57 (61) | 67 (72) | 74 (78) | 54 | Wild-type | |||
| 6 | 44 | 10 (29) | 33 (45) | 85 (68) | 97 (73) | 93 | Wild-type | |||
| 7 | 77 | 11 (18) | 12 (17) | 14 (20) | 15 (21) | 4 | Mutant (R175G) | |||
| 8 | 65 | 26 (30) | 71 (64) | 89 (74) | 94 (82) | 96 | Wild-type | |||
| 9 | 76 | 22 (20) | 61 (54) | 84 (76) | 84 (81) | 76 | Wild-type | |||
| 10 | 29 | 32 (11) | 61 (25) | 92 (38) | 98 (43) | 68 | Wild-type | |||
| 11 | 23 | 34 (26) | 32 (32) | 87 (64) | 84 (68) | 71 | Wild-type | |||
| 12 | 4 | 27 (16) | 40 (29) | 64 (50) | 79 (63) | 60 | Wild-type | |||
| 13 | 54 | 12 (14) | 36 (35) | 60 (52) | 78 (63) | 75 | Wild-type | |||
| 14 | 11 | 30 (42) | 58 (60) | 81 (70) | 91 (73) | 62 | Wild-type | |||
| 15 | 71 | 41 (34) | 57 (45) | 71 (67) | 83 (72) | 64 | Wild-type | |||
| 16 | 92 | 18 (22) | 60 (58) | 70 (71) | 88 (82) | 76 | Wild-type | |||
| 17 | 0 | 4 (15) | 7 (10) | 9 (15) | 10 (17) | 2 | Mutant (r248q) | |||
| 18 | 98 | 16 (15) | 21 (21) | 86 (85) | 97 (97) | 84 | Wild-type | |||
. | . | Annexin V+ in CD34+ fraction, % (in total MNC, %) . | . | . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient no. . | CD34+, % . | DMSO* . | 1 μM* . | 5 μM* . | 10 μM* . | Cell number reduction, %† . | p53 status . | |||
| 1 | 68 | 22 (27) | 36 (41) | 65 (67) | 84 (82) | 77 | Wild-type | |||
| 2 | 96 | 9 (11) | 49 (52) | 81 (82) | 87 (87) | 94 | Wild-type | |||
| 3 | 93 | 8 (11) | 31 (32) | 44 (47) | 76 (74) | 70 | Wild-type | |||
| 4 | 79 | 17 (19) | 39 (39) | 76 (66) | 91 (84) | 91 | Wild-type | |||
| 5 | 92 | 33 (32) | 57 (61) | 67 (72) | 74 (78) | 54 | Wild-type | |||
| 6 | 44 | 10 (29) | 33 (45) | 85 (68) | 97 (73) | 93 | Wild-type | |||
| 7 | 77 | 11 (18) | 12 (17) | 14 (20) | 15 (21) | 4 | Mutant (R175G) | |||
| 8 | 65 | 26 (30) | 71 (64) | 89 (74) | 94 (82) | 96 | Wild-type | |||
| 9 | 76 | 22 (20) | 61 (54) | 84 (76) | 84 (81) | 76 | Wild-type | |||
| 10 | 29 | 32 (11) | 61 (25) | 92 (38) | 98 (43) | 68 | Wild-type | |||
| 11 | 23 | 34 (26) | 32 (32) | 87 (64) | 84 (68) | 71 | Wild-type | |||
| 12 | 4 | 27 (16) | 40 (29) | 64 (50) | 79 (63) | 60 | Wild-type | |||
| 13 | 54 | 12 (14) | 36 (35) | 60 (52) | 78 (63) | 75 | Wild-type | |||
| 14 | 11 | 30 (42) | 58 (60) | 81 (70) | 91 (73) | 62 | Wild-type | |||
| 15 | 71 | 41 (34) | 57 (45) | 71 (67) | 83 (72) | 64 | Wild-type | |||
| 16 | 92 | 18 (22) | 60 (58) | 70 (71) | 88 (82) | 76 | Wild-type | |||
| 17 | 0 | 4 (15) | 7 (10) | 9 (15) | 10 (17) | 2 | Mutant (r248q) | |||
| 18 | 98 | 16 (15) | 21 (21) | 86 (85) | 97 (97) | 84 | Wild-type | |||