Table 4.

Summary of mtDNA heterogeneity in single CD34+ cells, T cells, B cells, and granulocytes




Heterogeneity

Poly-C tract
Cell type
Assay, no.*
Total rate,% (no.)
Unique, % (no.)
Substitution, % (no.)
np 303-315, % (no.)
CD34+ cells   456   37.9 ± 3.6 (173)  13.4 ± 2.2 (61)  14.7 ± 5.7 (67)  22.3 ± 9.3 (101)  
T cells   456   36.4 ± 14.1 (164)   18.6 ± 7.9 (84)  15.2 ± 9.0 (69)  21.5 ± 15.4 (96)  
B cells   442   36.0 ± 10.7 (160)   16.5 ± 2.5 (73)  15.4 ± 6.7 (69)  19.7 ± 13.4 (87)  
Granulocytes
 
376
 
47.7 ± 7.4 (178)
 
35.4 ± 4.1 (132)
 
32.3 ± 2.4 (121)
 
13.7 ± 10.2 (50)
 



Heterogeneity

Poly-C tract
Cell type
Assay, no.*
Total rate,% (no.)
Unique, % (no.)
Substitution, % (no.)
np 303-315, % (no.)
CD34+ cells   456   37.9 ± 3.6 (173)  13.4 ± 2.2 (61)  14.7 ± 5.7 (67)  22.3 ± 9.3 (101)  
T cells   456   36.4 ± 14.1 (164)   18.6 ± 7.9 (84)  15.2 ± 9.0 (69)  21.5 ± 15.4 (96)  
B cells   442   36.0 ± 10.7 (160)   16.5 ± 2.5 (73)  15.4 ± 6.7 (69)  19.7 ± 13.4 (87)  
Granulocytes
 
376
 
47.7 ± 7.4 (178)
 
35.4 ± 4.1 (132)
 
32.3 ± 2.4 (121)
 
13.7 ± 10.2 (50)
 

Np indicates nucleotide position.

*

All assays were from donor no. 5

Statistically significant difference (P < .05) from granulocytes

or Create an Account

Close Modal
Close Modal