Proportion of each cell population in nonerythroid cells cultured from JMML and normal BM cells
. | ZOL concentration, μM . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|
| . | Day 0 . | Day 10 . | . | . | . | ||||
. | 0 . | 0 . | 1 . | 10 . | 100 . | ||||
| JMML cells, % | |||||||||
| Granulocytes | 46 ± 7 | 2 ± 1 | 3 ± 2 | 30 ± 7 | 43 ± 5 | ||||
| Monocytes/macrophages | 30 ± 9 | 92 ± 2 | 88 ± 6 | 62 ± 9 | 51 ± 9 | ||||
| Lymphocytes | 11 ± 2 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | ||||
| Blasts | 13 ± 4 | 6 ± 2 | 9 ± 4 | 8 ± 1 | 6 ± 2 | ||||
| Normal BM cells, % | |||||||||
| Granulocytes | 77 ± 9 | 68 ± 9 | 69 ± 7 | 62 ± 6 | 75 ± 3 | ||||
| Monocytes/macrophages | 6 ± 4 | 28 ± 3 | 26 ± 4 | 38 ± 6 | 25 ± 3 | ||||
| Lymphocytes | 12 ± 4 | 4 ± 5 | 5 ± 4 | 0 ± 0 | 0 ± 0 | ||||
| Blasts | 5 ± 1 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | ||||
. | ZOL concentration, μM . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|
| . | Day 0 . | Day 10 . | . | . | . | ||||
. | 0 . | 0 . | 1 . | 10 . | 100 . | ||||
| JMML cells, % | |||||||||
| Granulocytes | 46 ± 7 | 2 ± 1 | 3 ± 2 | 30 ± 7 | 43 ± 5 | ||||
| Monocytes/macrophages | 30 ± 9 | 92 ± 2 | 88 ± 6 | 62 ± 9 | 51 ± 9 | ||||
| Lymphocytes | 11 ± 2 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | ||||
| Blasts | 13 ± 4 | 6 ± 2 | 9 ± 4 | 8 ± 1 | 6 ± 2 | ||||
| Normal BM cells, % | |||||||||
| Granulocytes | 77 ± 9 | 68 ± 9 | 69 ± 7 | 62 ± 6 | 75 ± 3 | ||||
| Monocytes/macrophages | 6 ± 4 | 28 ± 3 | 26 ± 4 | 38 ± 6 | 25 ± 3 | ||||
| Lymphocytes | 12 ± 4 | 4 ± 5 | 5 ± 4 | 0 ± 0 | 0 ± 0 | ||||
| Blasts | 5 ± 1 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | ||||
Each value (mean ± SD) was calculated from data for 3 patients with JMML (cases 4, 6, and 7) and healthy donors (cases 1, 3, and 5).