Cytokine and chemokine concentrations in lung homogenates
. | 2 weeks after administration . | . | 5 weeks after administration . | . | ||
|---|---|---|---|---|---|---|
. | WT . | TMpro/pro . | WT . | TMpro/pro . | ||
| IFN-γ | 191.2 ± 34.5 | 215.3 ± 52.8 | 219.3 ± 18.8 | 445.4 ± 70.8* | ||
| IL-4 | 23.5 ± 10.5 | 37.6 ± 8.5 | 488.3 ± 28.5 | 381.8 ± 28.5* | ||
| TNF-α | 461.2 ± 89.8 | 480.3 ± 135.3 | 376.6 ± 46.3 | 496.3 ± 55.2* | ||
| IL-10 | 44.4 ± 12.5 | 55.2 ± 0.9 | 235.3 ± 22.1 | 42.0 ± 21.3* | ||
| TGF-β | 380.4 ± 85.1 | 337.3 ± 79.9 | 1306.4 ± 155.7 | 812.2 ± 63.5* | ||
| MCP-1 | 458.2 ± 99.2 | 478.1 ± 78.4 | 154.2 ± 55.7 | 189.8 ± 17.1* | ||
| MIP-2 | 1978.2 ± 68.2 | 1800.6 ± 89.0 | 1581.2 ± 469.1 | 2363.4 ± 125.9* | ||
. | 2 weeks after administration . | . | 5 weeks after administration . | . | ||
|---|---|---|---|---|---|---|
. | WT . | TMpro/pro . | WT . | TMpro/pro . | ||
| IFN-γ | 191.2 ± 34.5 | 215.3 ± 52.8 | 219.3 ± 18.8 | 445.4 ± 70.8* | ||
| IL-4 | 23.5 ± 10.5 | 37.6 ± 8.5 | 488.3 ± 28.5 | 381.8 ± 28.5* | ||
| TNF-α | 461.2 ± 89.8 | 480.3 ± 135.3 | 376.6 ± 46.3 | 496.3 ± 55.2* | ||
| IL-10 | 44.4 ± 12.5 | 55.2 ± 0.9 | 235.3 ± 22.1 | 42.0 ± 21.3* | ||
| TGF-β | 380.4 ± 85.1 | 337.3 ± 79.9 | 1306.4 ± 155.7 | 812.2 ± 63.5* | ||
| MCP-1 | 458.2 ± 99.2 | 478.1 ± 78.4 | 154.2 ± 55.7 | 189.8 ± 17.1* | ||
| MIP-2 | 1978.2 ± 68.2 | 1800.6 ± 89.0 | 1581.2 ± 469.1 | 2363.4 ± 125.9* | ||
Data are mean values (in pg/mL) ± SE (n = 8 mice per group for each time point) at 2 and 5 weeks after intranasal administration of M tuberculosis (105 CFUs).
P <.05 versus WT.