Characteristics of patients with cardiovascular disease by β1-tubulin genotype
. | Noncarriers† . | Heterozygous β1-tubulin Q43P carriers† . | P . |
|---|---|---|---|
| No. | 543 | 30 | NA |
| Age, y | 56.6 ± 9.2 | 53.8 ± 9.0 | .10 |
| Female, % | 9.1 | 23.3 | .02* |
| Body mass index, kg/m2 | 25.5 ± 3.4 | 24.6 ± 3.4 | .15 |
| Triglyceride level, mM | 1.93 ± 1.19 | 1.61 ± .91 | .15 |
| Cholesterol level, mM | 5.56 ± 1.11 | 5.67 ± 1.25 | .61 |
| History of smoking, % | 71.1 | 83.4 | .22 |
| Diabetes mellitus, % | 6.1 | 0.0 | .32 |
| Hypertension, % | 28.4 | 10.0 | .04* |
| Family history, % | 20.0 | 20.0 | .99 |
| Myocardial infarction, % | 68.5 | 70.0 | .86 |
| Unstable angina, % | 4.3 | 6.7 | .86 |
| Coronary artery bypass graft, % | 38.2 | 46.7 | .45 |
| Coronary angioplasty, % | 58.3 | 50.0 | .48 |
| Effect of medication | |||
| Anticoagulation drugs, % | 5.5 | 6.7 | .79 |
| Antiplatelet drugs, % | 88.2 | 90.0 | .99 |
| Beta blockers, % | 84.3 | 83.3 | .88 |
| Lipid-lowering drugs, % | 16.4 | 30.0 | .09 |
| Ace inhibitors, % | 27.7 | 13.3 | .13 |
| Coronary heart disease, no. | 272 | 14 | NA |
| Single-vessel disease, % | 25 | 28.5 | .65 |
| Two-vessel disease, % | 25.7 | 28.5 | .65 |
| Three-vessel disease, % | 49.3 | 43.0 | .65 |
. | Noncarriers† . | Heterozygous β1-tubulin Q43P carriers† . | P . |
|---|---|---|---|
| No. | 543 | 30 | NA |
| Age, y | 56.6 ± 9.2 | 53.8 ± 9.0 | .10 |
| Female, % | 9.1 | 23.3 | .02* |
| Body mass index, kg/m2 | 25.5 ± 3.4 | 24.6 ± 3.4 | .15 |
| Triglyceride level, mM | 1.93 ± 1.19 | 1.61 ± .91 | .15 |
| Cholesterol level, mM | 5.56 ± 1.11 | 5.67 ± 1.25 | .61 |
| History of smoking, % | 71.1 | 83.4 | .22 |
| Diabetes mellitus, % | 6.1 | 0.0 | .32 |
| Hypertension, % | 28.4 | 10.0 | .04* |
| Family history, % | 20.0 | 20.0 | .99 |
| Myocardial infarction, % | 68.5 | 70.0 | .86 |
| Unstable angina, % | 4.3 | 6.7 | .86 |
| Coronary artery bypass graft, % | 38.2 | 46.7 | .45 |
| Coronary angioplasty, % | 58.3 | 50.0 | .48 |
| Effect of medication | |||
| Anticoagulation drugs, % | 5.5 | 6.7 | .79 |
| Antiplatelet drugs, % | 88.2 | 90.0 | .99 |
| Beta blockers, % | 84.3 | 83.3 | .88 |
| Lipid-lowering drugs, % | 16.4 | 30.0 | .09 |
| Ace inhibitors, % | 27.7 | 13.3 | .13 |
| Coronary heart disease, no. | 272 | 14 | NA |
| Single-vessel disease, % | 25 | 28.5 | .65 |
| Two-vessel disease, % | 25.7 | 28.5 | .65 |
| Three-vessel disease, % | 49.3 | 43.0 | .65 |