Changes in proportions of PNH blood-cell types during eculizumab treatment
. | Proportion of PNH cells, % . | . | . | . | ||
|---|---|---|---|---|---|---|
| PNH cell type . | Baseline§ . | 12 wk§ . | 64 wk§ . | P* . | ||
| Type III RBCs | ||||||
| All patients | 36.7 ± 5.9 | 59.2 ± 8.0 | 58.4 ± 8.5 | .005 | ||
| Patients without cytopenia† | 38.8 ± 3.7 | 73.5 ± 4.1 | 67.8 ± 7.0 | — | ||
| Patients with cytopenia‡ | 34.2 ± 12.9 | 42.1 ± 13.8 | 47.0 ± 16.3 | — | ||
| Type II RBCs | ||||||
| All patients | 5.3 ± 1.4 | 7.5 ± 2.1 | 13.2 ± 2.4 | .013 | ||
| Patients without cytopenia | 4.8 ± 1.8 | 6.8 ± 3.0 | 12.9 ± 1.9 | — | ||
| Patients with cytopenia | 5.8 ± 2.4 | 8.4 ± 3.2 | 13.5 ± 5.0 | — | ||
| Type III WBCs | ||||||
| All patients | 92.1 ± 4.6 | 89.9 ± 6.6 | 91.1 ± 5.8 | NS | ||
| Patients without cytopenia | 95.1 ± 2.3 | 94.9 ± 2.6 | 96.1 ± 1.1 | — | ||
| Patients with cytopenia | 88.4 ± 10.2 | 83.9 ± 14.5 | 85.2 ± 12.9 | — | ||
| Type III platelets | ||||||
| All patients | 92.4 ± 2.4 | 93.3 ± 2.8 | 92.8 ± 2.6 | NS | ||
| Patients without cytopenia | 93.2 ± 1.4 | 95.8 ± 2.1 | 95.0 ± 0.8 | — | ||
| Patients with cytopenia | 91.6 ± 5.4 | 90.2 ± 5.6 | 90.2 ± 5.8 | — | ||
. | Proportion of PNH cells, % . | . | . | . | ||
|---|---|---|---|---|---|---|
| PNH cell type . | Baseline§ . | 12 wk§ . | 64 wk§ . | P* . | ||
| Type III RBCs | ||||||
| All patients | 36.7 ± 5.9 | 59.2 ± 8.0 | 58.4 ± 8.5 | .005 | ||
| Patients without cytopenia† | 38.8 ± 3.7 | 73.5 ± 4.1 | 67.8 ± 7.0 | — | ||
| Patients with cytopenia‡ | 34.2 ± 12.9 | 42.1 ± 13.8 | 47.0 ± 16.3 | — | ||
| Type II RBCs | ||||||
| All patients | 5.3 ± 1.4 | 7.5 ± 2.1 | 13.2 ± 2.4 | .013 | ||
| Patients without cytopenia | 4.8 ± 1.8 | 6.8 ± 3.0 | 12.9 ± 1.9 | — | ||
| Patients with cytopenia | 5.8 ± 2.4 | 8.4 ± 3.2 | 13.5 ± 5.0 | — | ||
| Type III WBCs | ||||||
| All patients | 92.1 ± 4.6 | 89.9 ± 6.6 | 91.1 ± 5.8 | NS | ||
| Patients without cytopenia | 95.1 ± 2.3 | 94.9 ± 2.6 | 96.1 ± 1.1 | — | ||
| Patients with cytopenia | 88.4 ± 10.2 | 83.9 ± 14.5 | 85.2 ± 12.9 | — | ||
| Type III platelets | ||||||
| All patients | 92.4 ± 2.4 | 93.3 ± 2.8 | 92.8 ± 2.6 | NS | ||
| Patients without cytopenia | 93.2 ± 1.4 | 95.8 ± 2.1 | 95.0 ± 0.8 | — | ||
| Patients with cytopenia | 91.6 ± 5.4 | 90.2 ± 5.6 | 90.2 ± 5.8 | — | ||