Table 1. Effect of rapamycin on the... | American Society of Hematology

Table 1.

Effect of rapamycin on the inhibitory effects of imatinib mesylate and IFNα on leukemic CFU-GM progenitors

		% control colony formation
Case	Source	Rapamycin	IFNα	IFNα + rapamycin	imatinib mesylate	imatinib mesylate + rapamycin
1	PB	31	—	—	19	8
2^*	PB	30 ± 3	39 ± 4	19 ± 4	22 ± 6	5 ± 2
3	PB	48	53	23	23	14
4^*	BM	26 ± 4.5	54 ± 8	15 ± 2	—	—
5	BM	75	—	—	16	1.5
6	PB	34	70	13	—	—

		% control colony formation
Case	Source	Rapamycin	IFNα	IFNα + rapamycin	imatinib mesylate	imatinib mesylate + rapamycin
1	PB	31	—	—	19	8
2^*	PB	30 ± 3	39 ± 4	19 ± 4	22 ± 6	5 ± 2
3	PB	48	53	23	23	14
4^*	BM	26 ± 4.5	54 ± 8	15 ± 2	—	—
5	BM	75	—	—	16	1.5
6	PB	34	70	13	—	—

PB indicates peripheral blood;—, not done; and BM, bone marrow.

For cases 2 and 4, values shown are means ± SE of 2 independent experiments.