Table 2.

Kinetics of CD22+ B-cell recovery in B6 mice after injections of CD22/cal



Relative percentage of whole sample cells staining for CD22*
Tissue
Day 1
Day 12
Day 20
Day 30
Day 35
Day 40
Day 50
PB   42.9 ± 3.3   0.8 ± 0.5   1.1 ± 0.3   1.3 ± 0.9   4.5 ± 0.4   16.1 ± 1.4   35.6 ± 2.1  
Spleen   44.5 ± 2.2   0.9 ± 0.4   2.1 ± 0.2   13.5 ± 0.6   24.9 ± 2.5   42.2 ± 1.9   53.3 ± 1.9  
BM   26.7 ± 1.6   2.0 ± 0.3   1.6 ± 0.6   15.1 ± 1.0   19.1 ± 2.7   20.8 ± 1.5   27.3 ± 1.1  
LN
 
41 ± 2.5
 
0.9 ± 0.3
 
1.1 ± 0.5
 
1.4 ± 0.4
 
4.9 ± 1.3
 
15.8 ± 1.5
 
43.8 ± 1.7
 


Relative percentage of whole sample cells staining for CD22*
Tissue
Day 1
Day 12
Day 20
Day 30
Day 35
Day 40
Day 50
PB   42.9 ± 3.3   0.8 ± 0.5   1.1 ± 0.3   1.3 ± 0.9   4.5 ± 0.4   16.1 ± 1.4   35.6 ± 2.1  
Spleen   44.5 ± 2.2   0.9 ± 0.4   2.1 ± 0.2   13.5 ± 0.6   24.9 ± 2.5   42.2 ± 1.9   53.3 ± 1.9  
BM   26.7 ± 1.6   2.0 ± 0.3   1.6 ± 0.6   15.1 ± 1.0   19.1 ± 2.7   20.8 ± 1.5   27.3 ± 1.1  
LN
 
41 ± 2.5
 
0.9 ± 0.3
 
1.1 ± 0.5
 
1.4 ± 0.4
 
4.9 ± 1.3
 
15.8 ± 1.5
 
43.8 ± 1.7
 

Mice were given injections on days 0 and 5 with CD22/cal (160 μg/kg/ injection).

*

Numbers are the mean percentages (± SD) of 3 mice/time point