Hematologic effects of hydroxyurea dose escalation
Mean values . | Year 2; n = 21 . | Year 4; n = 17 . | Change in mean value . |
|---|---|---|---|
| Hb level, g/dL | 8.8 | 9.1 | +0.3 |
| MCV, fL | 90.0 | 95.1 | +5.1 |
| Hb F level, % | 20.3 | 23.7 | +3.4* |
| F cells, % | 76.2 | 82.6 | +6.4 |
| Reticulocyte count, % | 8.6 | 8.2 | –0.4 |
| WBC count, × 109/L | 10.1 | 10.1 | 0.0 |
| Platelets, × 109/L | 352.0 | 373.0 | +21.0 |
Mean values . | Year 2; n = 21 . | Year 4; n = 17 . | Change in mean value . |
|---|---|---|---|
| Hb level, g/dL | 8.8 | 9.1 | +0.3 |
| MCV, fL | 90.0 | 95.1 | +5.1 |
| Hb F level, % | 20.3 | 23.7 | +3.4* |
| F cells, % | 76.2 | 82.6 | +6.4 |
| Reticulocyte count, % | 8.6 | 8.2 | –0.4 |
| WBC count, × 109/L | 10.1 | 10.1 | 0.0 |
| Platelets, × 109/L | 352.0 | 373.0 | +21.0 |
Values at the end of year 4 (hydroxyurea dose: 30 mg/kg/d) are compared with those at the end of year 2 (hydroxyurea dose: 20 mg/kg/d).
P < .05