Rolling of platelet-leukocyte aggregates after infusion of activated platelets
. | . | Number of platelet-leukocyte aggregates rolling/min . | . | |
---|---|---|---|---|
Time after infusion, h . | Activation of infused platelets . | Aggregates with 10 or more platelets/leukocyte* . | Aggregates with about 3 platelets/leukocyte* . | |
0.25 | No | 0 | 0.19 ± 0.1 | |
0.25 | Yes | 5.9 ± 2.4 | 4.2 ± 0.9 | |
1 | Yes | 5.6 ± 1.4 | 11.1 ± 1.8 | |
2 | Yes | 0.5 ± 0.2 | 6.9 ± 2.3 | |
4 | Yes | 0 | 1.6 ± 0.2 |
. | . | Number of platelet-leukocyte aggregates rolling/min . | . | |
---|---|---|---|---|
Time after infusion, h . | Activation of infused platelets . | Aggregates with 10 or more platelets/leukocyte* . | Aggregates with about 3 platelets/leukocyte* . | |
0.25 | No | 0 | 0.19 ± 0.1 | |
0.25 | Yes | 5.9 ± 2.4 | 4.2 ± 0.9 | |
1 | Yes | 5.6 ± 1.4 | 11.1 ± 1.8 | |
2 | Yes | 0.5 ± 0.2 | 6.9 ± 2.3 | |
4 | Yes | 0 | 1.6 ± 0.2 |
The number of rolling platelet-leukocyte aggregates per minute was observed by fluorescence intravital microscopy at the indicated time points after infusion of calcein-labeled platelets and number of fluorescent platelets per leukocyte estimated.
Average ± SEM is shown