Table 6.

Analysis of baseline variables for their impact on hematologic response

Factors
No. subjects
No. subjects with hematologic response
Univariate P
Multivariate P(n = 56)
Sex     
Male   38   28   .179   NA  
Female   25   22    
Age*     
Younger than 60 y   38   33   .078   NA  
Older than 60 y   25   17    
Disease duration     
Fewer than 12 mo   16   14   .426   NA  
Longer than 12 mo   46   36    
Prior therapy     
None, HU, IFN   35   30   .170   NA  
Others   28   20    
Prior 6- Thioguanine     
Yes   58   46   .971   NA  
No   5   4    
Phase*     
Chronic   20   20   .005   NS  
Accelerated + blastic   43   30    
Clonal evolution*†     
Yes   25   16   .016   .010  
No   34   31    
Splenomegaly     
Yes   43   35   .772   NA  
No   13   10    
Hemoglobin level*     
At least 100 g/L   24   15   .016   NS  
Less than 100 g/L   38   34    
White blood cell count     
At least 10 × 109/L   19   16   .543   NA  
Fewer than 10 × 109/L   44   34    
Platelet count*     
No more than 100 × 109/L   16   9   .095   NS  
More than 100 × 109/L but less than 450 × 109/L   28   24    
More than 450   17   14    
Blasts in PB*‡     
5% or less   41   38   <.001   .001  
Greater than 5%   20   10    
Basophils in PB     
7% or less   42   32   .540   NA  
Greater than 7%   18   15    
Blasts in BM     
5% or less   29   29   .942   NA  
Greater than 5%   25   15    
Mutation     
Yes   14   9   .123   NA  
No
 		 49
 		 41
 
 
 
Factors
No. subjects
No. subjects with hematologic response
Univariate P
Multivariate P(n = 56)
Sex     
Male   38   28   .179   NA  
Female   25   22    
Age*     
Younger than 60 y   38   33   .078   NA  
Older than 60 y   25   17    
Disease duration     
Fewer than 12 mo   16   14   .426   NA  
Longer than 12 mo   46   36    
Prior therapy     
None, HU, IFN   35   30   .170   NA  
Others   28   20    
Prior 6- Thioguanine     
Yes   58   46   .971   NA  
No   5   4    
Phase*     
Chronic   20   20   .005   NS  
Accelerated + blastic   43   30    
Clonal evolution*†     
Yes   25   16   .016   .010  
No   34   31    
Splenomegaly     
Yes   43   35   .772   NA  
No   13   10    
Hemoglobin level*     
At least 100 g/L   24   15   .016   NS  
Less than 100 g/L   38   34    
White blood cell count     
At least 10 × 109/L   19   16   .543   NA  
Fewer than 10 × 109/L   44   34    
Platelet count*     
No more than 100 × 109/L   16   9   .095   NS  
More than 100 × 109/L but less than 450 × 109/L   28   24    
More than 450   17   14    
Blasts in PB*‡     
5% or less   41   38   <.001   .001  
Greater than 5%   20   10    
Basophils in PB     
7% or less   42   32   .540   NA  
Greater than 7%   18   15    
Blasts in BM     
5% or less   29   29   .942   NA  
Greater than 5%   25   15    
Mutation     
Yes   14   9   .123   NA  
No
 		 49
 		 41
 
 
 

NS indicates not significant; NA, not available.

*

Factors with P < .1 in univariate analysis were included in the multivariate model.

†

Estimated odds ratio = .086; 95% Wald confidence interval = 0.013-0.568.

‡

Estimated odds ratio = .050; 95% Wald confidence interval = 0.008-0.322.

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