List of annotated genes that displayed more than 2-fold changes following IRF-8 induction
Unigene ID . | Gene name (gene symbol) . | Clone name . | Fold change, IRF-8/control . |
|---|---|---|---|
| Endosomal/lysozomal enzyme-related genes | |||
| Mm.4263 | Cystatin C (Cst3) | H3033F11 | 10.6 |
| Mm.45436 | Lysozyme M (Lyzs) | H3054F05 | 10.6 |
| Mm.180056 | Cathepsin C (Ctsc) | H3037F12, H3055G02 | 7.6, 7.6 |
| Mm.277498 | Prosaposin (Psap) | H3151D11 | 5.3 |
| Mm.930 | Cathepsin L (Ctsl) | H3028F03 | 2.1 |
| Signal transduction-related genes | |||
| Mm.191749 | Phosphodiesterase 4A, cAMP specific (Pde4a) | H3037G12 | 6.0 |
| Mm.28262 | Regulator of G-protein signaling 2 (Rgs2) | H3053A12 | 4.0 |
| Mm.317331 | v-yes-1 oncogene homolog (Lyn) | H3001B08 | 3.5 |
| Mm.2314 | Protein kinase C, delta (Prkcd) | H3059B03 | 3.2 |
| Mm.275839 | Janus kinase 2 (Jak2) | H3067C12 | 2.4 |
| Cell growth-related genes | |||
| Mm.2444 | Myelocytomatosis oncogene (Myc) | H3076D10, H3089H11 | 0.38, 0.34 |
| Mm.333406 | Cyclin D2 (Ccnd2) | H3026D04 | 2.1 |
| Mm.217318 | Microtubule-associated protein 4 (Mtap4) | H3058E07 | 2.1 |
| Cytoskeleton-related genes | |||
| Mm.3532 | Thymosin, beta 10 (Tmsb10) | H3001H10 | 3.8 |
| Mm.240839 | Tropomyosin 3, gamma (Tpm3) | H3022F08 | 3.2 |
| Mm.6384 | Nebulin-related anchoring protein (Nrap) | H3020G05 | 2.4 |
| Others | |||
| Mm.295578 | Tripartite motif protein 30 (Trim30/Rpt1) | H3063C08 | 3.1 |
| Mm.66056 | Membrane bound C2 domain containing protein (Mbc2) | H3094D04 | 2.6 |
| Mm.290906 | Nuclear antigen Sp100 (Sp100) | H3052B09 | 2.5 |
| Mm.16373 | Histocompatibility 2, class II, locus DMa (H2-DMa) | H3109E03 | 2.3 |
| Mm.193021 | Rho GTPase activating protein 17 (Arhgap17) | H3100H08 | 2.6 |
| Mm.248327 | C-type lectin, superfamily member 9 (Clecsf9) | H3053D08 | 2.0 |
| Mm.253061 | Ankyrin repeat and SOCS box-containing protein 13 (Asb13) | H3051A11 | 2.0 |
Unigene ID . | Gene name (gene symbol) . | Clone name . | Fold change, IRF-8/control . |
|---|---|---|---|
| Endosomal/lysozomal enzyme-related genes | |||
| Mm.4263 | Cystatin C (Cst3) | H3033F11 | 10.6 |
| Mm.45436 | Lysozyme M (Lyzs) | H3054F05 | 10.6 |
| Mm.180056 | Cathepsin C (Ctsc) | H3037F12, H3055G02 | 7.6, 7.6 |
| Mm.277498 | Prosaposin (Psap) | H3151D11 | 5.3 |
| Mm.930 | Cathepsin L (Ctsl) | H3028F03 | 2.1 |
| Signal transduction-related genes | |||
| Mm.191749 | Phosphodiesterase 4A, cAMP specific (Pde4a) | H3037G12 | 6.0 |
| Mm.28262 | Regulator of G-protein signaling 2 (Rgs2) | H3053A12 | 4.0 |
| Mm.317331 | v-yes-1 oncogene homolog (Lyn) | H3001B08 | 3.5 |
| Mm.2314 | Protein kinase C, delta (Prkcd) | H3059B03 | 3.2 |
| Mm.275839 | Janus kinase 2 (Jak2) | H3067C12 | 2.4 |
| Cell growth-related genes | |||
| Mm.2444 | Myelocytomatosis oncogene (Myc) | H3076D10, H3089H11 | 0.38, 0.34 |
| Mm.333406 | Cyclin D2 (Ccnd2) | H3026D04 | 2.1 |
| Mm.217318 | Microtubule-associated protein 4 (Mtap4) | H3058E07 | 2.1 |
| Cytoskeleton-related genes | |||
| Mm.3532 | Thymosin, beta 10 (Tmsb10) | H3001H10 | 3.8 |
| Mm.240839 | Tropomyosin 3, gamma (Tpm3) | H3022F08 | 3.2 |
| Mm.6384 | Nebulin-related anchoring protein (Nrap) | H3020G05 | 2.4 |
| Others | |||
| Mm.295578 | Tripartite motif protein 30 (Trim30/Rpt1) | H3063C08 | 3.1 |
| Mm.66056 | Membrane bound C2 domain containing protein (Mbc2) | H3094D04 | 2.6 |
| Mm.290906 | Nuclear antigen Sp100 (Sp100) | H3052B09 | 2.5 |
| Mm.16373 | Histocompatibility 2, class II, locus DMa (H2-DMa) | H3109E03 | 2.3 |
| Mm.193021 | Rho GTPase activating protein 17 (Arhgap17) | H3100H08 | 2.6 |
| Mm.248327 | C-type lectin, superfamily member 9 (Clecsf9) | H3053D08 | 2.0 |
| Mm.253061 | Ankyrin repeat and SOCS box-containing protein 13 (Asb13) | H3051A11 | 2.0 |
Tot2 cells transduced with ER (control) or IRF-8/ER were treated with β-estradiol for 4 hours and analyzed with the NIA 15K cDNA microarray. Two independent experiments were performed to identify genes differentially expressed between the two samples with a statistical significance of P below .05 by t test.