Estimated relative risks for a first episode of venous thromboembolism (VTE) in individuals with a thrombophilic defect as compared to individuals without a defect; derived from family and population-based case-control studies.
| Thrombophilic Defect . | Estimated Relative Risk . | References . |
|---|---|---|
| Antithrombin deficiency | 8–10 | Martinelli I.
Blood 1998 ;92 :2353 –2358.Simioni P. Thromb Haemost . 1999 ;81 :198 –202. |
| Protein C deficiency | 7–10 | Martinelli I.
Blood 1998 ;92 :2353 –2358.Simioni P. Thromb Haemost . 1999 ;81 :198 –202. |
| Protein S deficiency | 8–10 | Martinelli I.
Blood 1998 ;92 :2353 –2358.Simioni P. Thromb Haemost. 1999 ;81 :198 –202. |
| Factor V Leiden/APC resistance | 3–7 | Middeldorp S.
Ann Int Med. 1998 ;128 :15 –20.Koster T. Lancet. 1993 ;342 :1503 –1506. |
| Prothrombin 20210A mutation | 3 | Poort SR. Blood. 1996 ;88 :3698 –3703. |
| Elevated factor VIII:c (dose-dependent) | 2–11 | Koster T.
Lancet. 1995 ;345 :152 –155.Kraaijenhagen RA. Thromb Haemost. 2000 ;83 :5 –9. |
| Elevated factor IX:c | 2–3 | van Hylckama Vlieg A. Blood. 2000 ;95 :3678 –3682. |
| Elevated factor XI:c (> 90th percentile) | 2 | Meijers JCM. N Eng J Med . 2000 ;342 :696 –701. |
| Mild hyperhomocysteinemia (fasting or post-methionine loading) | 2.5–2.6 | den Heijer M. Thromb Haemost . 1998 ;80 :874 –877. |
| Anticardiolipin antibodies | Wahl DG. Lupus . 1998 ;7 :15 –22 | |
| all | 1.6 | |
| high titers only | 3.2 | |
| Lupus anticoagulant | 11 | Wahl DG. Lupus . 1998 ;7 :15 –22. |
| Thrombophilic Defect . | Estimated Relative Risk . | References . |
|---|---|---|
| Antithrombin deficiency | 8–10 | Martinelli I.
Blood 1998 ;92 :2353 –2358.Simioni P. Thromb Haemost . 1999 ;81 :198 –202. |
| Protein C deficiency | 7–10 | Martinelli I.
Blood 1998 ;92 :2353 –2358.Simioni P. Thromb Haemost . 1999 ;81 :198 –202. |
| Protein S deficiency | 8–10 | Martinelli I.
Blood 1998 ;92 :2353 –2358.Simioni P. Thromb Haemost. 1999 ;81 :198 –202. |
| Factor V Leiden/APC resistance | 3–7 | Middeldorp S.
Ann Int Med. 1998 ;128 :15 –20.Koster T. Lancet. 1993 ;342 :1503 –1506. |
| Prothrombin 20210A mutation | 3 | Poort SR. Blood. 1996 ;88 :3698 –3703. |
| Elevated factor VIII:c (dose-dependent) | 2–11 | Koster T.
Lancet. 1995 ;345 :152 –155.Kraaijenhagen RA. Thromb Haemost. 2000 ;83 :5 –9. |
| Elevated factor IX:c | 2–3 | van Hylckama Vlieg A. Blood. 2000 ;95 :3678 –3682. |
| Elevated factor XI:c (> 90th percentile) | 2 | Meijers JCM. N Eng J Med . 2000 ;342 :696 –701. |
| Mild hyperhomocysteinemia (fasting or post-methionine loading) | 2.5–2.6 | den Heijer M. Thromb Haemost . 1998 ;80 :874 –877. |
| Anticardiolipin antibodies | Wahl DG. Lupus . 1998 ;7 :15 –22 | |
| all | 1.6 | |
| high titers only | 3.2 | |
| Lupus anticoagulant | 11 | Wahl DG. Lupus . 1998 ;7 :15 –22. |