Properties of umbilical cord blood (UCB) cell populations relevant to immune responsiveness.
| Hematopoietic Stem Cells . | Dendritic Cells . | T Lymphocytes . |
|---|---|---|
| Abbreviations: IL, interleukin; INF, interferon | ||
| Decreased number | Decreased immune activity | Decreased number |
| Increased cell cycling | Decreased co-stimulation | Naive phenotype |
| Increased generative capacity | Decreased IL-12 production | Resistance to activation |
| More immature? | Decreased cytokine expression | |
| Skewing to Th2 responses (decreased IL-2, INF-γ production) | ||
| Hematopoietic Stem Cells . | Dendritic Cells . | T Lymphocytes . |
|---|---|---|
| Abbreviations: IL, interleukin; INF, interferon | ||
| Decreased number | Decreased immune activity | Decreased number |
| Increased cell cycling | Decreased co-stimulation | Naive phenotype |
| Increased generative capacity | Decreased IL-12 production | Resistance to activation |
| More immature? | Decreased cytokine expression | |
| Skewing to Th2 responses (decreased IL-2, INF-γ production) | ||