Table 1. Concentrations of TKI levels in... | American Society of Hematology

Table 1.

Concentrations of TKI levels in murine plasma at steady-state condition after 4 days of treatment and 2 and 24 hours after oral administration

Agent	2 h, ng/mL*	24 h, ng/mL*
Ponatinib, 3 mg/kg twice daily	176 ± 47†	11.42 ± 3.4‡
Imatinib, 180 mg/kg twice daily	17 367 ± 4840	876 ± 60

Agent	2 h, ng/mL*	24 h, ng/mL*
Ponatinib, 3 mg/kg twice daily	176 ± 47†	11.42 ± 3.4‡
Imatinib, 180 mg/kg twice daily	17 367 ± 4840	876 ± 60

Values represent mean ± standard deviation (SD) of 3 values for each agent collected on days 4-5 at 2 and 24 hours after dosing on day 4. Groups of treated mice were given the agent twice daily for 4 d before sample collection.

†

Value is 33 ± 8.8 nM (mean ± SD).

‡

Value is 2.1 ± 0.6 nM (mean ± SD).

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